Titre : | Efficacy and safety of e-cigarette use for smoking cessation: A systematic review and meta-analysis of randomized controlled trials (2023) |
Auteurs : | J. Y. LEVETT ; K. B. FILION ; P. REYNIER ; C. PRELL ; M. J. EISENBERG |
Type de document : | Article : Périodique |
Dans : | American Journal of Medicine (Vol.136, n°8, August 2023) |
Article en page(s) : | 804-813.e804 |
Langues: | Anglais |
Discipline : | EPI (Epidémiologie / Epidemiology) |
Mots-clés : |
Thésaurus mots-clés ETUDE RANDOMISEE ; TABAC ; ARRET DU TABAC ; E-CIGARETTE ; EFFICACITE ; SECURITE ; SEVRAGE ; ABSTINENCE ; NICOTINE |
Résumé : |
BACKGROUND: People who smoke conventional cigarettes are increasingly turning to electronic cigarettes (e-cigarettes) as a pathway to quitting. However, the efficacy and safety of e-cigarettes for smoking cessation remains controversial.
METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), identified through a systematic search of the MEDLINE, EMBASE, and Cochrane CENTRAL databases. Inclusion was restricted to RCTs with a follow-up duration >=6 months. The primary endpoint was the most rigorous criterion of biochemically validated abstinence at maximum follow-up, and the primary comparison was nicotine e-cigarettes versus any conventional (ie, non-e-cigarette) smoking cessation therapy. The Cochrane Risk of Bias Tool was used to assess bias. Count data were pooled across trials using random-effects models with inverse variance weighting to estimate relative risks (RRs) and corresponding 95% confidence intervals (CIs). We registered the study protocol with the Open Science Framework Registries (osf.io/26fkq). RESULTS: A total of 5 RCTs (n = 3253) were included. Compared with conventional smoking cessation therapies, the use of nicotine e-cigarettes was associated with an increase in abstinence, defined by the most rigorous criterion of abstinence reported (RR 1.77; 95% CI, 1.29-2.44). Nicotine e-cigarettes also increased abstinence (defined by the most rigorous criterion) compared with non-nicotine e-cigarettes (RR 1.56; 95% CI, 1.13-2.15). The incidence of death or serious adverse events was low across all trials at maximum follow-up. CONCLUSIONS: Among individuals attempting to quit smoking, nicotine e-cigarettes are more efficacious than conventional nicotine replacement or behavioral smoking cessation therapies, and may prove beneficial in reducing smoking-related health risks. |
Domaine : | Tabac / Tobacco / e-cigarette |
Sous-type de document : | Méta-analyse / Meta-analysis ; Revue de la littérature / Literature review |
Refs biblio. : | 23 |
Affiliation : |
Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital/McGill University, Montreal, QC, Canada; Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; Department of Medicine, McGill University, Montreal, QC, Canada |
Lien : | https://doi.org/10.1016/j.amjmed.2023.04.014 |
Accueil