Titre : | Case report of a fatal 3-hydroxyphencyclidine intoxication, including blood and hair results (2023) |
Auteurs : | A. AMELINE ; M. BAUDRY ; D. GARNIER ; J. S. RAUL ; P. KINTZ |
Type de document : | Article : Périodique |
Dans : | Journal of Analytical Toxicology (Vol.47, n°6, July 2023) |
Article en page(s) : | 552-556 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés ETUDE DE CAS ; INTOXICATION ; PHENCYCLIDINE ; DROGUES DE SYNTHESE ; ANALYSE CHIMIQUE ; MORT ; SANG ; PHANERES |
Résumé : | 3-hydroxyphencyclidine (3-OH-PCP) is a hydroxy derivative of phencyclidine, synthesized in 1978 to investigate the structure-activity relationship of phencyclidine derivates. In vitro studies have shown that 3-OH-PCP, like phencyclidine, acts on the NMDA receptor and has a higher affinity for this receptor than phencyclidine. The authors report the case of a 38-year-old man, known for drug addiction, found dead at home with two plastic bags of powders found near his body. Using LC-MS/MS, peripheral blood toxicological analysis revealed consumption of 3-OH-PCP with a concentration of 3-OH-PCP at 524 ng/mL. Blood also tested positive for nordiazepam, methylphenidate, amisulpride, methadone and benzoylecgonine, all at concentrations near those observed after recreational abuse. The blood concentration of 3-OH-PCP is the highest ever reported in the literature. Hair testing also revealed 3-OH-PCP, at 174 pg/mg, which may correspond to a chronic consumption of this molecule. A NMR analysis of the two powders highlighted 3-OH-PCP and 5-Meo-DMT, estimated at 85.4% and 91.3% of purity, respectively, using the Electronic Reference To access in vivo Concentrations (ERETIC) method. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Etude de cas / Case report |
Refs biblio. : | 18 |
Affiliation : |
Institut de médecine légale, Strasbourg, France. Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199, Illkirch-Graffenstaden, France Plateforme d'Analyse Chimique de Strasbourg-Illkirch, Illkirch-Graffenstaden, France X-Pertise Consulting, Mittelhausbergen, France |
Lien : | https://doi.org/10.1093/jat/bkad031 |
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