Historique
Article de Périodique
Suitability of high-resolution mass spectrometry in analytical toxicology: Focus on drugs of abuse (2022)
Auteur(s) :
R. GONCALVES ;
R. PELLETIER ;
A. COUETTE ;
T. GICQUEL ;
B. LE DARE
Article en page(s) :
29-41
Sous-type de document :
Revue de la littérature / Literature review
Refs biblio. :
112
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
TOXICOLOGIE
;
ANALYSE CHIMIQUE
;
DROGUES DE SYNTHESE
;
METABOLISME
;
DEPISTAGE
;
METHODE
;
MESURES QUANTITATIVES
;
MESURES QUALITATIVES
;
BASE DE DONNEES
Résumé :
High-resolution mass spectrometry (HRMS) is now the method of choice in several toxicology contexts. This paper reviews HRMS approaches for research and application in various toxicology fields, focusing on drugs of abuse in clinical and forensic toxicology. Papers concerning HRMS applications in screening, quantification and metabolism of drugs of abuse in biological and non-biological samples were included. Specific applications for new psychoactive substances in contexts such as online libraries, bioinformatic tools (molecular networking) and methods combinations were also included.
Affiliation :
Forensic and Clinical Toxicology Laboratory, CHU de Bordeaux, Bordeaux, France