|Titre :||Trends and characteristics of naloxone therapy reported to US poison centers (2018)|
|Auteurs :||S. V. REGE ; D. A. NGO ; N. AIT-DAOUD ; S. SHARMA ; E. VERPLANCKEN ; C. P. HOLSTEGE|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.113, n°12, December 2018)|
|Article en page(s) :||2309-2315|
|Note générale :||Commentary: Naloxone reports to US poison centers highlight overdose prevention opportunities. Oliva E.M., Bounthavong M., p. 2316-2317.|
|Discipline :||EPI (Epidémiologie / Epidemiology)|
Thésaurus TOXIBASECENTRE ANTIPOISON ; NALOXONE ; REDUCTION DES RISQUES ; OPIOIDES ; SURDOSE ; EVOLUTION ; EPIDEMIOLOGIE ; GEOGRAPHIE
BACKGROUND AND AIMS: In the United States, access to naloxone has been expanded as a measure to address growing opioid overdose mortality. The study aimed to describe the national trends in naloxone use as reported to the US poison centers (PCs).
METHODS: The National Poison Data System (NPDS) was queried for cases reporting naloxone therapy from 1 January 2001 to 31 December 2016. Demographic and clinical characteristics were assessed descriptively. Trends in naloxone reports were evaluated by using generalized linear mixed models that were adjusted for age, gender and random effects of the geographical census region. Cumulative incidence rates (CIR) of naloxone reports at the state- and national-level were calculated.
RESULTS: There were 304 249 cases reporting naloxone therapy during the study period. The frequency of naloxone reports increased from 9498 in 2000 to 26 826 in 2016. The proportion of cases where naloxone was used prior to PC recommendation increased from 59.8% in 2000 to 81.5% in 2016. The mean number of NPDS naloxone reports per 100 000 human exposures increased from 9.6 [95% confidence interval (CI) = 6.4-14.2] to 31.7 (95% CI = 21.4-46.9, P CONCLUSIONS: Analysis of calls to the United States poison centers indicates an increasing trend of naloxone use from 2000 to 2016.
|Domaine :||Autres substances / Other substances ; Drogues illicites / Illicit drugs|
|Refs biblio. :||54|
|Affiliation :||Department of Emergency Medicine, Division of Medical Toxicology, University of Virginia School of Medicine, Charlottesville, VA, USA|