Titre : | Rapid, secure drug testing using fingerprint development and paper spray mass spectrometry (2017) |
Auteurs : | C. COSTA ; R. WEBB ; V. PALITSIN ; M. ISMAIL ; M. DE PUIT ; S. ATKINSON ; M. J. BAILEY |
Type de document : | Article : Périodique |
Dans : | Clinical Chemistry (Vol.63, n°11, November 2017) |
Article en page(s) : | 1745-1752 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés TOXICOLOGIE ; ANALYSE CHIMIQUE ; DEPISTAGE ; METHODE ; COCAINE |
Mots-clés: | emprunte |
Résumé : |
Background: Paper spray mass spectrometry6 is a technique that has recently emerged and has shown excellent analytical sensitivity to a number of drugs in blood. As an alternative to blood, fingerprints have been shown to provide a noninvasive and traceable sampling matrix. Our goal was to validate the use of fingerprint samples to detect cocaine use.
Methods: Samples were collected on triangular pieces (168 mm²) of washed Whatman Grade I chromatography paper. Following application of internal standard, spray solvent and a voltage were applied to the paper before mass spectrometry detection. A fingerprint visualization step was incorporated into the analysis procedure by addition of silver nitrate solution and exposing the sample to ultraviolet light. Results: Limits of detection for cocaine, benzoylecgonine, and methylecgonine were 1, 2, and 31 ng/mL respectively, with relative standard deviations Conclusions: The method offers a qualitative and noninvasive screening test for cocaine use. The analysis method developed is rapid (4 min/sample) and requires no sample preparation. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 30 |
Affiliation : | University of Surrey, Ion Beam Centre, Surrey, UK |
URL : | http://www.europe1.fr/sante/la-consommation-de-cocaine-est-desormais-detectable-grace-aux-empreintes-digitales-3444329 |
Lien : | https://doi.org/10.1373/clinchem.2017.275578 |
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