| Titre : | A 6-year review of new psychoactive substances at the Centre antipoison Grand-Ouest d'Angers: Clinical and biological data (2017) |
| Auteurs : | A. TURCANT ; M. DEGUIGNE ; S. FÉREC ; C. BRUNEAU ; I. LEBORGNE ; B. LELIÈVRE ; C. GEGU ; F. JEGOU ; C. ABBARA ; G. LE ROUX ; D. BOELS |
| Type de document : | Article : Périodique |
| Dans : | Toxicologie Analytique et Clinique (Vol.29, n°1, Février 2017) |
| Article en page(s) : | 18-33 |
| Langues: | Anglais |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés CENTRE ANTIPOISON ; DROGUES DE SYNTHESE ; PHENOMENE EMERGENT ; DEPISTAGE ; TOXICOLOGIE ; CATHINONES ; EFFET SECONDAIRE ; KETAMINE ; ETUDE DE CAS ; CANNABINOIDES ; ANALYSE CHIMIQUE |
| Résumé : | For the last 10 years, recreational use of new psychoactive substances (NPS) with hallucinogenic properties was more and more described either in a context of consumption during a rave-party or at home alone or in small group. A review of 62 cases (56 M, 6 F, 16-46 y) registered from 2011 to 2016 at the French Grand Ouest centre antipoison of Angers is presented. Some of them (n = 15) presented a severe clinical state (poison severity score, PSS = 3) and only one was a fatal intoxication (PSS = 4). Treatment of acute intoxication was mainly based on supportive care with a quick recovery in less than 48 h. A high number of these cases were documented by plasma (pl) and/or urine analyses using LC-UV, GC-MS and LC-MS². Several powders or other forms bought on the web market by the patients were also analysed. Six amphetamines derivates were detected such as methiopropamine (pl: 50 - 430 µg/L, n = 6) or 5 others (6-APB, 6-APDB, 5-EAPB, 5-MAPB, 2-FA each once). Four 2,5-dimethoxy-derivates of phenylethylamines (2Cs) or of amphetamines (DOs) were detected as 2C-P (pl: |
| Domaine : | Autres substances / Other substances ; Drogues illicites / Illicit drugs |
| Refs biblio. : | 48 |
| Affiliation : | Laboratoire de pharmacologie-toxicologie, institut de biologie en santé, CHU d’Angers, Angers, France |
| Cote : | Abonnement |
| Lien : | http://www.sciencedirect.com/science/journal/23520078/29/1 |
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