Historique
Article de Périodique
Lethal poisonings with AH-7921 in combination with other substances (2014)
Auteur(s) :
R. KARINEN ;
S. S. TUV ;
S. ROGDE ;
M. D. PERES ;
U. JOHANSEN ;
J. FROST ;
V. VINDENES ;
A. M. L. OIESTAD
Article en page(s) :
e21-e24
Refs biblio. :
31
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
TOXICOLOGIE
;
DROGUES DE SYNTHESE
;
ANALYSE CHIMIQUE
;
MORTALITE
;
ETUDE DE CAS
;
MEDECINE LEGALE
;
POLYCONSOMMATION
Thésaurus géographique
NORVEGE
Résumé :
AH-7921 is a synthetic μ-opioid agonist, approximately equipotent with morphine. We report the death of two young individuals after ingestion of AH-7921 in combination with other psychoactive drugs.
In the first case a young man died shortly after ingesting Internet drugs. Toxicological analysis of post mortem peripheral blood revealed AH-7921 (0.43 mg/L), 2-FMA (0.0069 mg/L) and 3-MMC (0.0021 mg/L) as well as codeine (0.42 mg/L), codeine-6-glucuronide (0.77 mg/L) and acetaminophen (18.7 mg/L).
The second case involved a young female found dead at home. The only positive finding at medicolegal autopsy was needle marks. Toxicological analysis revealed AH-7921 (0.33 mg/L), methoxetamine (MXE) (0.064 mg/L), etizolam (0.27 mg/L), phenazepam (1.33 mg/L), 7-aminonitrazepam (0.043 mg/L), diazepam (0.046 mg/L), nordiazepam (0.073 mg/L), and oxazepam (0.018 mg/L) in blood.
In both cases intoxication with AH-7921 in combination with other psychoactive drugs was considered to be the cause of death.
Highlights:
We present two case reports of lethal poisonings with AH-7921 in combination with other substances.
Toxicological findings are discussed.
An UPLC-MS/MS method for the quantitative determination of AH-7921, 2-FMA and 3-MMC.
In the first case a young man died shortly after ingesting Internet drugs. Toxicological analysis of post mortem peripheral blood revealed AH-7921 (0.43 mg/L), 2-FMA (0.0069 mg/L) and 3-MMC (0.0021 mg/L) as well as codeine (0.42 mg/L), codeine-6-glucuronide (0.77 mg/L) and acetaminophen (18.7 mg/L).
The second case involved a young female found dead at home. The only positive finding at medicolegal autopsy was needle marks. Toxicological analysis revealed AH-7921 (0.33 mg/L), methoxetamine (MXE) (0.064 mg/L), etizolam (0.27 mg/L), phenazepam (1.33 mg/L), 7-aminonitrazepam (0.043 mg/L), diazepam (0.046 mg/L), nordiazepam (0.073 mg/L), and oxazepam (0.018 mg/L) in blood.
In both cases intoxication with AH-7921 in combination with other psychoactive drugs was considered to be the cause of death.
Highlights:
We present two case reports of lethal poisonings with AH-7921 in combination with other substances.
Toxicological findings are discussed.
An UPLC-MS/MS method for the quantitative determination of AH-7921, 2-FMA and 3-MMC.
Affiliation :
Norwegian Institute of Public Health, Division of Forensic Sciences, Oslo, Norway