Titre : | Lethal poisonings with AH-7921 in combination with other substances (2014) |
Auteurs : | R. KARINEN ; S. S. TUV ; S. ROGDE ; M. D. PERES ; U. JOHANSEN ; J. FROST ; V. VINDENES ; A. M. L. OIESTAD |
Type de document : | Article : Périodique |
Dans : | Forensic Science International (Vol.244, November 2014) |
Article en page(s) : | e21-e24 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés TOXICOLOGIE ; DROGUES DE SYNTHESE ; ANALYSE CHIMIQUE ; MORTALITE ; ETUDE DE CAS ; MEDECINE LEGALE ; POLYCONSOMMATIONThésaurus géographique NORVEGE |
Résumé : |
AH-7921 is a synthetic μ-opioid agonist, approximately equipotent with morphine. We report the death of two young individuals after ingestion of AH-7921 in combination with other psychoactive drugs.
In the first case a young man died shortly after ingesting Internet drugs. Toxicological analysis of post mortem peripheral blood revealed AH-7921 (0.43 mg/L), 2-FMA (0.0069 mg/L) and 3-MMC (0.0021 mg/L) as well as codeine (0.42 mg/L), codeine-6-glucuronide (0.77 mg/L) and acetaminophen (18.7 mg/L). The second case involved a young female found dead at home. The only positive finding at medicolegal autopsy was needle marks. Toxicological analysis revealed AH-7921 (0.33 mg/L), methoxetamine (MXE) (0.064 mg/L), etizolam (0.27 mg/L), phenazepam (1.33 mg/L), 7-aminonitrazepam (0.043 mg/L), diazepam (0.046 mg/L), nordiazepam (0.073 mg/L), and oxazepam (0.018 mg/L) in blood. In both cases intoxication with AH-7921 in combination with other psychoactive drugs was considered to be the cause of death. Highlights: We present two case reports of lethal poisonings with AH-7921 in combination with other substances. Toxicological findings are discussed. An UPLC-MS/MS method for the quantitative determination of AH-7921, 2-FMA and 3-MMC. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 31 |
Affiliation : | Norwegian Institute of Public Health, Division of Forensic Sciences, Oslo, Norway |
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