Titre : | Acute combined poisoning with the new designer drug 4-methyl-N-ethyl-cathinone (4-MEC) and gammabutyrolactone (GBL): A case report with different analytical approaches for identification of some metabolites (2014) |
Auteurs : | A. TURCANT ; D. BOELS ; A. G. HELFER ; S. FÉREC ; M. BRETAUDEAU DEGUIGNE ; B. LELIÈVRE ; M. R. MEYER ; H. H. MAURER |
Type de document : | Article : Périodique |
Dans : | Toxicologie Analytique et Clinique (Vol.26, n°3, Septembre 2014) |
Article en page(s) : | 119-127 |
Note générale : | Erratum: Toxicologie Analytique et Clinique, 2015:27(3), p. 212. |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés ETUDE DE CAS ; INTOXICATION ; CATHINONES ; DROGUES DE SYNTHESE ; GBL ; METABOLITE ; ANALYSE CHIMIQUE ; TOXICOLOGIE |
Résumé : | Objective: 4-Methyl-N-ethylcathinone (4-MEC) is a novel designer drug of the beta-keto amphetamine family. A case of a mixed poisoning by 4-MEC and gamma-butyrolactone (GBL) is described. Two and half hours after an injected 0.25-0.5 g 4-MEC dose and thirty minutes after GBL ingestion, a 39-year-old man became unconscious and presented after admission to the hospital, transient apnea needing oxygenation and stimulation. After 30 min, he woke up, but remained confused for 4 hours. He was discharged 13 hours later without particular symptoms. For confirmation of the poisoning, different analytical procedures such as HPLC-UV/DAD, GC-MS, UPLC-MS/MS, and LC-HR-MS/MS were applied. Blood and urine levels (8 h after injection) were respectively 353 µg/L and 100 mg/L for 4-MEC and 300 mg/L and 1000 mg/L for gamma-hydroxybutyric acid. In urine, three metabolites (dihydro-, nor-, and nor-dihydro-4-MEC) could be identified for the first time and were similar to those described for other molecules of this class. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Etude de cas / Case report |
Refs biblio. : | 20 |
Affiliation : | Laboratoire de pharmacologie-toxicologie, Institut de biologie en santé, Centre hospitalier universitaire, Angers, France |
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