| Titre : | Buprenorphine implants for treatment of opioid dependence: randomized comparison to placebo and sublingual buprenorphine/naloxone (2013) |
| Auteurs : | R. N. ROSENTHAL ; W. LING ; P. CASADONTE ; F. VOCCI ; G. L. BAILEY ; K. KAMPMAN ; A. A. PATKAR ; S. CHAVOUSTIE ; C. BLASEY ; S. C. SIGMON ; K. L. BEEBE |
| Type de document : | Article : Périodique |
| Dans : | Addiction (Vol.108, n°12, December 2013) |
| Article en page(s) : | 2141-2149 |
| Note générale : | Commentary: Buprenorphine implant - new hopes, old questions. Basu D., p. 2150-2151. |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus géographique ETATS-UNISThésaurus mots-clés ETUDE RANDOMISEE ; BUPRENORPHINE ; COMPARAISON ; VOIE D'ADMINISTRATION ; TRAITEMENT DE MAINTENANCE ; OPIOIDES ; EFFICACITE ; PRODUIT DE SUBSTITUTION |
| Résumé : |
Aims: To evaluate the safety and efficacy of buprenorphine implants (BI) versus placebo implants (PI) for the treatment of opioid dependence. A secondary aim compared BI to open-label sublingual buprenorphine/naloxone tablets (BNX).
Design: Randomized, double-blind, placebo-controlled trial. Subjects received either four buprenorphine implants (80 mg/implant) (n = 114), four placebo implants (n = 54) or open-label BNX (12-16 mg/day) (n = 119). Setting: Twenty addiction treatment centers. Participants: Adult out-patients (ages 18-65) with DSM-IV-TR opioid dependence. Measurements: The primary efficacy end-point was the percentage of urine samples negative for opioids collected from weeks 1 to 24, examined as a cumulative distribution function (CDF). Findings: The BI CDF was significantly different from placebo (P Conclusions: Compared with placebo, buprenorphine implants result in significantly less frequent opioid use and are non-inferior to sublingual buprenorphine/naloxone tablets. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 21 |
| Affiliation : | Department of Psychiatry, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA |
| Cote : | Abonnement |
| Lien : | http://dx.doi.org/10.1111/add.12315 |
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