Historique
Article de Périodique
Neurobiology of addiction: an integrative review (2008)
Auteur(s) :
A. GOODMAN
Article en page(s) :
266-322
Refs biblio. :
1136
Domaine :
Addictions sans produit / Addictions without drug ; Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ADDICTION
;
DEPENDANCE
;
BOULIMIE
;
NEUROBIOLOGIE
;
JEU PATHOLOGIQUE
;
CONCEPT
;
DEFINITION
;
CERVEAU
;
MECANISME D'ACTION
;
NEUROTRANSMETTEURS
;
RECEPTEUR
Résumé :
Evidence that psychoactive substance use disorders, bulimia nervosa, pathological gambling, and sexual addiction share an underlying biopsychological process is summarized. Definitions are offered for addiction and addictive process, the latter being the proposed designation for the underlying biopsychological process that addictive disorders are hypothesized to share. The addictive process is introduced as an interaction of impairments in three functional systems: motivation-reward, affect regulation, and behavioral inhibition. An integrative review of the literature that addresses the neurobiology of addiction is then presented, organized according to the three functional systems that constitute the addictive process. The review is directed toward identifying candidate neurochemical substrates for the impairments in motivation-reward, affect regulation, and behavioral inhibition that could contribute to an addictive process.
Affiliation :
Minnesota Institute of Psychiatry, 1347 Summit Avenue, St. Paul, MN 55105, USA