|Titre :||A comparison of levomethadyl acetate, buprenorphine and methadone for opioid dependence (2000)|
|Auteurs :||R. E. JOHNSON ; M. A. CHUTUAPE ; E. C. STRAIN ; S. L. WALSH ; M. L. STITZER ; G. E. BIGELOW|
|Type de document :||Article : Périodique|
|Dans :||New England Journal of Medicine (Vol.343, n°18, November 2, 2000)|
|Article en page(s) :||1290-1297|
|Discipline :||TRA (Traitement et prise en charge / Treatment and care)|
Thésaurus TOXIBASEOPIACES ; BUPRENORPHINE ; METHADONE ; ENQUETE ; EVALUATION ; LAAM
BACKGROUND: Opioid dependence is a chronic, relapsing disorder with important public health implications.
METHODS: In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75 to 115 mg), buprenorphine (16 to 32 mg), and high-dose (60 to 100 mg) and low-dose (20 mg) methadone as treatments for opioid dependence. Levomethadyl acetate and buprenorphine were administered three times a week. Methadone was administered daily. Doses were individualized except in the group assigned to low-dose methadone. Patients with poor responses to treatment were switched to methadone.
RESULTS: There were 55 patients in each group; 51 percent completed the trial. The mean (+/-SE) number of days that a patient remained in the study was significantly higher for those receiving levomethadyl acetate (89+/-6), buprenorphine (96+/-4), and high-dose methadone (105+/-4) than for those receiving low-dose methadone (70+/-4, P CONCLUSIONS: As compared with low-dose methadone, levomethadyl acetate, buprenorphine, and high-dose methadone substantially reduce the use of illicit opioids.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||48|
|Affiliation :||Royaume-Uni. United Kingdom.|
|Centre Emetteur :||13 OFDT|