Historique
Article de Périodique
A characterisation of patient drop outs in a cohort of HIV positive homosexual/bisexual men and intraveinous drug users (2001)
Auteur(s) :
POOLE, W. K. ;
SHAH, K. B. ;
LOU Y. ;
TURNER, J. ;
KVALE P. ;
HOPEWELL P. C. ;
GLASSROTH J. ;
ROSEN, M. ;
REICHMAN L. ;
WALLACE, J.
Année :
2001
Page(s) :
66-67
Langue(s) :
Anglais
Refs biblio. :
2
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
USAGER
;
VOIE INTRAVEINEUSE
;
HSH
;
COHORTE
;
SIDA
;
RETENTION
;
MODELE
;
MODELE STATISTIQUE
;
METHODE
;
EPIDEMIOLOGIE
Résumé :
Enrollees in a study who cease participation for one reason or another can create problems for those who analyse and interpret the data. These problems include loss of statistical power, bias in the study results, and lack of generalisability of the study findings. Whether the study is a clinical trial or an observational study these problems may exist. In trials, for example, non-random withdrawals may compromise the comparability between the treatment groups and hence introduce a bias and in observational studies selective withdrawal may limit the generalisability of the study results. Much has been written about the consequences of non-random withdrawals and some authors have offered statistical techniques that can effectively adjust for the resulting bias if certain assumptions are met. Although it is not generally possible to compensate for all of the problems created by attrition, certain considerations like statistical power and adequate representation of important subgroups can be attained in the design if one can identify high attrition groups during planning. Hence, the identification of prognostic factors for attrition is important. That is the aim of this article for a special subgroup of the population. [Extract]
Affiliation :
Research Triangle Institute, Research Triangle Park, North Carolina, USA, Glaxo-Wellcome, University of California, San Francisco, San Francisco, California, USA