Titre : | A controlled trial of buprenorphine treatment for opioid dependence |
Titre traduit : | (Essai de distribution contrôlée de buprenorphine dans le traitement de la dépendance aux opiacés) |
Auteurs : | R. E. JOHNSON ; J. H. JAFFE ; P. J. FUDALA |
Type de document : | Périodique |
Année de publication : | 1992 |
Format : | 2750-2755 / graph. ; tabl. |
Note générale : |
Journal of the American Medical Association (Edition Francaise), 1992, 267, (20), 2750-2755 |
Langues: | Français |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; EVALUATION ; ENQUETE ; ABSTINENCEThésaurus géographique ETATS-UNIS |
Résumé : |
ENGLISH : OBJECTIVE. To assess the efficacy of buprenorphine for short-term maintenance/detoxification. DESIGN--A randomized, double-blind, parallel group study comparing buprenorphine, 8 mg/d, methadone, 60 mg/d, and methadone, 20 mg/d, in a 17-week maintenance phase followed by an 8-week detoxification phase. SETTING. Outpatient facilities at the Addiction Research Center, Baltimore, Md. PATIENTS. One hundred sixty-two volunteers seeking treatment for opioid dependence. INTERVENTION--In addition to the medication, counselling using a relapse prevention model was offered but not required. PRIMARY OUTCOME MEASURES. Retention time in treatment, urine samples negative for opioids, and failure to maintain abstinence. RESULTS. Throughout the maintenance phase, retention rates were significantly greater for buprenorphine (42%) than for methadone, 20 mg/d (20%, P less than .04); the percentage of urine samples negative for opioids was significantly greater for buprenorphine (53%, P less than .001) and methadone, 60 mg/d (44%, P less than .04), than for methadone, 20 mg/d (29%). Failure to maintain abstinence during the maintenance phase was significantly greater for methadone, 20 mg/d, than for buprenorphine (P less than .03). During the detoxification phase, no differences were observed between groups with respect to urine samples negative for opioids. For the entire 25 weeks, retention rates for buprenorphine (30%, P less than .01) and methadone, 60 mg/d (20%, P less than .05), were significantly greater than for methadone, 20 mg/d (6%). All treatments were well tolerated, with similar profiles of self-reported adverse effects. The percentages of patients who received counselling did not differ between groups. CONCLUSIONS. Buprenorphine was as effective as methadone, 60 mg/d, and both were superior to methadone, 20 mg/d, in reducing illicit opioid use and maintaining patients in treatment for 25 weeks. (Review' s abstract) |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 45 |
Affiliation : |
Addiction Research Center, National Institute on Drug Abuse, Baltimore, Md Etats-Unis. United States. |
Numéro Toxibase : | 1300409 |
Centre Emetteur : | 13 OFDT |
Cote : | A00479 |
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