Historique
Article de Périodique
Routes of infection, viremia and liver disease in blood donors found to have hepatitis C virus infection (1996)
Auteur(s) :
CONRY-CANTILENA C. ;
VANRADEN M. ;
GIBBLE J. ;
MELPOLDER J. ;
SHAKIL A. O. ;
L. VILADOMIU ;
L. CHEUNG ;
DIBISCEGLIE A. ;
HOOFNAGLE J. ;
J. W. SHIH
Article en page(s) :
1691-1696
Refs biblio. :
33
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
HEPATITE
;
PATHOLOGIE
;
FOIE
;
ENQUETE
;
CONTAMINATION
;
FACTEUR DE RISQUE
;
ANALYSE CHIMIQUE
;
MESURES QUANTITATIVES
;
PRISE DE SANG
Note générale :
New England Journal of Medicine, 1996, 334, (26), 1691-1696
Résumé :
BACKGROUND: For many people infected with the hepatitis C virus (HCV), the route of exposure, risk of transmission, and severity of associated liver disease are unknown. We studied these variables in people who donated blood voluntarily. METHODS: Blood donors who tested positive for HCV antibodies on enzyme immunoassay were classified according to whether the results of a confirmatory second-generation recombinant immunoblot assay (RIBA) for HCV were positive, negative, or indeterminate. The evaluations also included an assessment of risk factors, a physical examination, serial determinations of alanine aminotransferase levels and HCV serologic assays, a polymerase-chain-reaction assay for HCV RNA, testing of sexual contacts and family members, and liver biopsies in some participants who were HCV-positive by RIBA. RESULTS: A total of 481 donors were studied, among whom 248 were positive for HCV by RIBA, 102 had indeterminate results, and 131 were HCV-negative. In a logistic-regression analysis, significant risk factors for HCV infection among the HCV-positive participants were a history of blood transfusion in 66 (27 percent; P
Affiliation :
Dpt of Transfusion Medicine, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20892
Royaume-Uni. United Kingdom.
Royaume-Uni. United Kingdom.