| Titre : | Routes of infection, viremia and liver disease in blood donors found to have hepatitis C virus infection (1996) |
| Auteurs : | CONRY-CANTILENA C. ; VANRADEN M. ; GIBBLE J. ; MELPOLDER J. ; SHAKIL A. O. ; L. VILADOMIU ; L. CHEUNG ; DIBISCEGLIE A. ; HOOFNAGLE J. ; J. W. SHIH |
| Type de document : | Article : Périodique |
| Dans : | New England Journal of Medicine (Vol.334, n°26, June 27, 1996) |
| Article en page(s) : | 1691-1696 |
| Note générale : | New England Journal of Medicine, 1996, 334, (26), 1691-1696 |
| Langues: | Anglais |
| Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
| Mots-clés : |
Thésaurus mots-clés HEPATITE ; PATHOLOGIE ; FOIE ; ENQUETE ; CONTAMINATION ; FACTEUR DE RISQUE ; ANALYSE CHIMIQUE ; MESURES QUANTITATIVES ; PRISE DE SANG |
| Résumé : | BACKGROUND: For many people infected with the hepatitis C virus (HCV), the route of exposure, risk of transmission, and severity of associated liver disease are unknown. We studied these variables in people who donated blood voluntarily. METHODS: Blood donors who tested positive for HCV antibodies on enzyme immunoassay were classified according to whether the results of a confirmatory second-generation recombinant immunoblot assay (RIBA) for HCV were positive, negative, or indeterminate. The evaluations also included an assessment of risk factors, a physical examination, serial determinations of alanine aminotransferase levels and HCV serologic assays, a polymerase-chain-reaction assay for HCV RNA, testing of sexual contacts and family members, and liver biopsies in some participants who were HCV-positive by RIBA. RESULTS: A total of 481 donors were studied, among whom 248 were positive for HCV by RIBA, 102 had indeterminate results, and 131 were HCV-negative. In a logistic-regression analysis, significant risk factors for HCV infection among the HCV-positive participants were a history of blood transfusion in 66 (27 percent; P |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 33 |
| Affiliation : |
Dpt of Transfusion Medicine, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20892 Royaume-Uni. United Kingdom. |
| Centre Emetteur : | 13 OFDT |
| Lien : | http://www.nejm.org/doi/full/10.1056/NEJM199606273342602 |
Accueil
