Titre : | Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice |
Auteurs : | DALTERIO S. ; A. BARTKE ; MAYFIELD D. |
Type de document : | Périodique |
Année de publication : | 1981 |
Format : | 581-583 |
Note générale : |
Science, 1981, 213, (4507), 581-583 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés TETRAHYDROCANNABINOL ; MODELE ANIMAL ; EFFET SECONDAIRE ; VOIE ORALE ; SEXUALITE ; SANGThésaurus géographique ETATS-UNIS |
Résumé : |
ENGLISH : Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses. In hypophysectomized and intact mice receiving gonadotropins (human chorionic gonadotropin), treatment with delta 9-tetrahydrocannabinol maintained higher plasma testosterone concentrations. Thus, this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 17 |
Affiliation : |
Departments of Pharmacology and Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284 Etats-Unis. United States. |
Centre Emetteur : | 13 OFDT |
Cote : | A01014 |
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