Titre : | Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study |
Titre traduit : | (La tiabagine augmente l'abstinence à la cocaïne chez des cocaïnomanes en traitement de maintenance à la méthadone : résultats d'une étude pilote randomisée.) |
Auteurs : | G. GONZALES ; SEVARINO K. ; M. SOFUOGLU ; J. POLING ; A. OLIVETO ; GONSAI K. ; T. P. GEORGE ; T. R. KOSTEN |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 1625-1632 / fig. |
Note générale : |
Addiction, 2003, 98, (11), 1625-1632 |
Langues: | Français |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; TRAITEMENT ; GABA ; NEUROTRANSMETTEURS ; EFFICACITE |
Résumé : |
FRANÇAIS : La tigabine, substance GABAérgique, diminue l'auto-administration de la cocaïne. Son efficacité et son absence de nocivité sont évaluées chez 45 cocaïnomanes en traitement de maintenance à la méthadone. A une posologie de 24mg/jour, la tiagabine est bien tolérée et les dépistages urinaires posititifs à la cocaïne ont diminué de 33% après 9 à 10 semaines de traitement. ENGLISH : Aims: We sought to evaluate the safety and efficacy of the GABAergic agent tiagabine in reducing cocaine use among methadone-treated patients. Design: Ten-week randomized double-blind placebo-controlled trial. Setting: Opiate Treatment Research Program, Veteran's Affairs Connecticut Healthcare System in West Haven, Connecticut. USA. Participants: The participants were 45 cocaine-dependent methadone-treated patients who were predominately Caucasian (75.6%), male (77.8'%) and never married (53'%) with an average age of 38 years (SD= 6.5). Interventions: Comparison groups received tiagabine 12 mg/day (n = 15), tiagabine 24 mg/day (n= 15) or placebo (n= 15). Measures: Baseline assessments included the Structured Clinical Interview for DSM-IV, the Addiction Severity Index, a urine drug test, self reported use and opiate withdrawal scales. Urine drug tests were performed thrice weekly. Findings: Treatment retention was over 80% for all treatment groups. The sample mean (+SE) of cocaine-free urines for the first week after study entry and before tiagabine was started was 1.16 (0.19) urines/week. During weeks 9 and 10 cocaine-free urines increased significantly from baseline by 33 % with high-dose tiagabine (24 mg/day), by 14% with low-dose tiagabine (12 mg/day) and decreased by 10% with placebo (hierarchical linear model, Z = 2.03: P |
Note de contenu : | fig. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 38 |
Affiliation : |
VA Connecticut Healthcare System, Dept Psychiatry 116A4, 950 Campbell Ave, Bldg 36, West Haven, CT 06516. E-mail: Gerardo.Gonzales-Haddadyale.edu Etats-Unis. United States. |
Numéro Toxibase : | 207212 |
Centre Emetteur : | 02 Coordonnateur |
Cote : | A01899 |
Exemplaires
Disponibilité |
---|
aucun exemplaire |
Accueil