Titre : | Concentration-effect relationship of delta-9-tetrahydrocannabiol and prediction of psychotropic effects after smoking marijuana |
Auteurs : | HARDER S. ; RIETBROCK S. |
Type de document : | Périodique |
Année de publication : | 1997 |
Format : | 155-159 |
Note générale : |
International Journal of Clinical Pharmacology and Therapeutics, 1997, 35, (4), 155-159 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés TETRAHYDROCANNABINOL ; MECANISME D'ACTION ; MESURES QUANTITATIVES ; CANNABIS |
Résumé : |
ENGLISH : On the basis of a publication by Cochetto et al. [1981] we performed simulations of the effect-time course (high-rating) after smoking marijuana. The intention was to characterize the concentration-effect relationship of THC and to provide information on how long psychotropic effects (and therefore impairment of cognitive or motoric functions) last after intake of a cannabinoid product. The parameter estimates (+/-SD) of the pharmacokinetic disposition and the pharmacodynamic model (sigmoidal Emax model) after smoking 1 marijuana cigarette containing 9 mg THC were as follows: T/2 alpha = 5 minutes (+/-1.2), T/2 beta = 75 minutes (+/-23), Teq (equilibrium half-life with the effect site) = 29 minutes. (+/-2), ECe50 = 7.2 ng/ml THC (+/-0.5), E0 (baseline high rating) = 18% (+/-2.0), Emax (amplitude of the high rating) = 23% (+/-2.5), Hill coefficient = 9.0 (+/-3.0). On the basis of this curve fit, the effect-time course after repeated smoking (5 joints) in different intervals (120, 60, and 30 minutes) and for different dose strengths 9 mg (standard joint), 3 mg (weak joint) and 1 mg (agricultural hemp) were simulated. The duration of the effect after 1 dose of 9 mg is about 45 minutes. After the last cigarette, recovery (decline |
Domaine : | Drogues illicites / Illicit drugs |
Affiliation : |
Department Clinical Pharmacology, University Hospital Frankfurt/Main Allemagne. Germany. |
Centre Emetteur : | 13 OFDT |
Cote : | A02035 |
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