Historique
Périodique
Two cases of "cannabis acute psychosis" following the administration of oral cannabis
(deux cas de psychose aigüe dûe au cannabis suite à une ingestion de cannabis par voie orale)
Auteur(s) :
FAVRAT, B. ;
MENETREY, A. ;
AUGSBURGER, M. ;
ROTHUIZEN, L. E. ;
APPENZELLER, M. ;
BUCLIN, T. ;
PIN, M. ;
MANGIN, P. ;
GIROUD, C.
Année :
2005
Page(s) :
6 p.
Langue(s) :
Français
Refs biblio. :
26
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
VOIE D'ADMINISTRATION
;
ETUDE DE CAS
;
TROUBLE BIPOLAIRE
;
CANNABIS
;
PSYCHOSE
;
VOIE ORALE
;
PARANOIA
;
TETRAHYDROCANNABINOL
Thésaurus géographique
SUISSE
Note générale :
BMC Psychiatry, 2005, 5, (17)
Note de contenu :
graph.
Résumé :
ENGLISH :
Background: Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. Case presentations: We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented. Conclusion: While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur. (Author' s abstract)
Affiliation :
Unité de Médecine du Trafic, Institut Universitaire de Médecine Légale (IUML), 1005 Lausanne. Email : bernard.favrat@hospvd.ch
Suisse. Switzerland.
Suisse. Switzerland.
Cote :
A02208