Titre : | Use of SPE and LC/TIS/MS/MS for rapid detection and quantification of ketamine and its metabolite, norketamine, in urine |
Titre traduit : | (Utilisation de la SPE (extraction de phase solide) et de la LC/TIS/MSMS (chromatographie liquide et spectrometrie de masse) pour le dépistage rapide et le dosage dans l'urine de la kétamine et de son métabolite, la norkétamine) |
Auteurs : | K. C. WANG ; T. S. SHIH ; S. G. CHENG |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 81-88 / tabl. |
Note générale : |
Forensic Science International, 2005, 147, (1), 81-88 |
Langues: | Français |
Discipline : | PRE (Prévention - RdRD / Prevention - Harm reduction) |
Mots-clés : |
Thésaurus mots-clés KETAMINE ; DEPISTAGE ; METHODE ; TEST ; URINE ; MESURES QUANTITATIVES |
Résumé : |
ENGLISH : Ketamine (K) has become more and more popular for drug abuse in recent years. A lot of pre-treatment work such as extraction and derivatizing increase difficulties in the tests for ketamine in biological specimens. A rapid method to detect and quantitate ketamine and its metabolite norketamine in urine used deuterated dilution followed by solid phase extraction and liquid chromatography/TurbolonSpray/tandem mass spectrometry (LC/TIS/MS/MS) is described. Control recovery for both low and high concentrations can reach to 90%. Ten ketamine positive urines were examinated by this method. Concentrations ranged from 114 to 2925 ng/mL and from 453 to 9805 ng/mL for norketamine. The method was sensitive, specific, accurate and provided easy operation to detect and quantitate ketamine and its metabolites in urine. |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 18 |
Affiliation : | Taiwan. Taiwan. |
Numéro Toxibase : | 1301245 |
Centre Emetteur : | 13 OFDT |
Cote : | A02318 |
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