|Titre :||Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS (2005)|
|Titre original:||(Causes de décès chez les adultes infectés au VIH à l'ère de la thérapie antiretrovirale : place grandissante de l'hépatite et des cancers, rôle stable du Sida)|
|Auteurs :||C. LEWDEN ; D. SALMON ; P. MORLAT ; S. BEVILACQUA ; E. JOUGLA ; F. BONNET ; HERIPRET L. ; D. COSTAGLIOLA ; T. MAY ; G. CHENE ; THE MORTALITY 2000 STUDY GROUP|
|Type de document :||Article : Périodique|
|Dans :||International Journal of Epidemiology (Vol.34, n°1, February 2005)|
|Article en page(s) :||121-130|
|Discipline :||EPI (Epidémiologie / Epidemiology)|
Thésaurus TOXIBASEMORTALITE ; VIH ; HEPATITE ; SIDA ; ENQUETE ; CANCER ; IMMIGRATION ; PATHOLOGIE ORGANIQUE
Background: In the era of highly active antiretroviral therapy (HAART) mortality has decreased substantially among human immunodeficiency virus (HIV)-infected people with access to HAART, but there are concerns regarding co-morbidities and adverse effects of HAART, which may impair vital prognosis. The Mortality 2000 study examined the causes of death in HIV-infected adults at a national level in France in the year 2000.
Methods: All French hospital wards known to be involved in the management of HIV infection were asked to notify prospectively the deaths that occurred in 2000 among HIV-infected adults. The causes of death were documented using a standardized questionnaire.
Results: The 185 participating wards notified 964 deaths. The main underlying causes of death were AIDS-related (47%, non-Hodgkin's lymphoma: 23%), viral hepatitis (11%, hepatitis C: 9%, hepatitis B: 2%), cancer not related to AIDS or hepatitis (11%), cardiovascular disease (7%), bacterial infections (6%), suicide (4%), and adverse effect of antiretroviral treatments (1%). Among AIDS-related deaths, HIV infection had been diagnosed recently in 20%. Smoking was recorded in 72% of cancer-related deaths and alcohol consumption in 54% of hepatitis-related deaths. Among non-HIV related deaths between 25 and 64 years, the proportion of infectious diseases (including HCV and HBV-related deaths) was higher in HIV-infected adults than in the general population.
Conclusions: Improved strategies for detecting HIV infection before AIDS-defining complications occur are needed in the era of HAART. The prevention of non-AIDS related cancers, especially lung cancer, the management of non-Hodgkin's lymphoma, and of viral hepatitis are also important priorities.
|Domaine :||Plusieurs produits / Several products|
|Refs biblio. :||33|
|Affiliation :||INSERM U593 (exU330), Bordeaux, France|
|Numéro Toxibase :||1301311|
|Centre Emetteur :||13 OFDT|
|URL :||Commentary: https://doi.org/10.1093/ije/dyh402|