Titre : | Surveillance of HIV and viral hepatitis by analysis of samples from drug related deaths (2006) |
Titre traduit : | (Surveillance du VIH et de l'hépatite virale par l'examen des échantillons en provenance des décès liés à la drogue) |
Auteurs : | P. B. CHRISTENSEN ; KRINGSHOLM B. ; J. BANNER ; THOMSEN J.L. ; COWAN S. ; G. F. STEIN ; JURGENSEN G.W. ; K. GRASAASEN ; GEORGEN J. ; C. PEDERSEN |
Type de document : | Article : Périodique |
Dans : | European Journal of Epidemiology (Vol.21, n°5, May 2006) |
Article en page(s) : | 383-387 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés VIH ; MORTALITE ; MEDECINE LEGALE ; ENQUETE ; PREVALENCE ; METHODEThésaurus géographique DANEMARK |
Résumé : | Objectives: To determine the prevalence of antibodies against HIV, hepatitis B (HBV) and hepatitis C (HCV) in postmortem samples from drug related deaths (DRDs) in Denmark. Design: Prospective cohort study. Postmortem samples tested for anti-HIV, anti-HCV anti-HBc and anti-HBs. Comparison to pre-mortem testing when possible. DRDs were searched for in the national register of drug treatment, national prison registers, and the national infectious disease register. Setting: National level. Participants: Drug related deaths admitted to Danish Institutes of Forensic Medicine during 2004. Main outcome measures: Prevalence of antibodies, injection drug use, drug treatment experience and prevalence of cirrhosis. Results: Samples for analysis were obtained from 78% (233/299) of DRDs. The prevalences of anti-HIV, anti-HCV and anti-HBc were 4% (9/214), 51% (110/215), and 35% (74/209), indicating a persisting low prevalence of HIV and a declining prevalence of HCV and HBV. Injecting ever was detected among 45% of DRDs and this was associated with a significantly higher prevalence of hepatitis B and C. Among the DRDs 56% received drug treatment and 12% had cirrhosis at autopsy. Evidence of vaccination against HBV was found among 16% (21/128). Conclusions: Monitoring of viral hepatitis and HIV among DRDs is feasible, and our survey indicates a falling prevalence among Danish drug users. Surveillance based on drug users in treatment may overestimate the true prevalence. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 19 |
Affiliation : | Department of Infectious Diseases, Odense University Hospital, Odense C, Denmark |
Numéro Toxibase : | 1301626 |
Centre Emetteur : | 13 OFDT |
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