Titre : | Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine (2003) |
Titre traduit : | (Une dose faible de gamma-vinyl GABA (vigabatrine) inhibe les augmentations de dopamine dues à la cocaïne dans le noyau accumbens) |
Auteurs : | W. K. SCHIFFER ; D. MARSTELLER ; S. L. DEWEY |
Type de document : | Article : Périodique |
Dans : | Psychopharmacology (Vol.168, n°3, July 2003) |
Article en page(s) : | 339-343 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; DOPAMINE ; NEUROBIOLOGIE ; MODELE ANIMAL ; PHARMACOTHERAPIE ; VISION |
Résumé : | RATIONALE: gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism. OBJECTIVES: Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA). METHODS: Using in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period. RESULTS: Sub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose. CONCLUSIONS: Sub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 36 |
Affiliation : |
Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794. Etats-Unis. United States. |
Numéro Toxibase : | 1301668 |
Centre Emetteur : | 13 OFDT |
Cote : | A02842 |
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