Titre : | Positive CAGE screen correlates with cirrhosis in veterans with chronic hepatitis C |
Auteurs : | KAMAL A. ; CHEUNG R. |
Type de document : | Périodique |
Année de publication : | 2007 |
Format : | 1-6 |
Note générale : |
Digestive Diseases and Sciences, 2007, (Online First 6 April), 1-6 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés DEPISTAGE ; HEPATITE ; CIRRHOSE ; ALCOOL ; QUESTIONNAIRE ; ENQUETE ; COHORTEThésaurus géographique ETATS-UNIS |
Résumé : |
ENGLISH : The current study examines the relationship between problem alcohol use and severity of liver disease by self-administered questionnaires using both the CAGE questionnaire and beverage-specific quantity-frequency questions. The cohort consisted of 38 patients with cirrhosis (10 with decompensated liver disease) and 62 with mild fibrosis (stage 0-1), of comparable mean age and estimated duration of infection. Although mean alcohol consumption was similar in both groups, a positive CAGE screen (defined as two or more affirmative answers) was significantly more common among cirrhotics (OR = 5.24; 95% CI, 1.78-15.39) and tended to be associated with decompensated liver disease (OR = 13.3; 95% CI, 0.67-256) among cirrhotics. In multivariate analysis, only inflammatory grade on liver biopsy (OR = 67.7; 95% CI, 10.6-431) and positive CAGE score (OR = 8.09; 95% CI, 1.15-57.1) were independent predictors of cirrhosis. These findings suggest that the CAGE questionnaire predicts advanced liver disease better than daily or lifetime drinking measures. (Author' s abstract) |
Domaine : | Alcool / Alcohol |
Refs biblio. : | 33 |
Affiliation : |
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94305, and Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, 94304. Email : rcheung@stanford.edu Etats-Unis. United States. |
Centre Emetteur : | 13 OFDT |
Cote : | A03308 |
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