Titre : | Impact of maternal HIV coinfection on the vertical transmission of hepatitis C virus: a meta-analysis |
Auteurs : | C. B. POLIS ; S. N. SHAH ; K. E. JOHNSON ; A. GUPTA |
Type de document : | Périodique |
Année de publication : | 2007 |
Format : | 1123-1131 |
Note générale : |
Clinical Infectious Diseases, 2007, 44, (8), 1123-1131
|
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés HEPATITE ; INFECTION ; MERE ; ENFANT ; CONTAMINATION ; VIH |
Résumé : | BACKGROUND: Observational studies suggest that maternal human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection is associated with increased odds of vertical HCV transmission. We performed a meta-analysis to summarize current evidence. METHODS: We systematically searched for relevant articles published during the period from January 1992 through July 2006 and independently abstracted articles that met our inclusion criteria. Under a random effects model, we calculated the pooled odds ratio for vertical HCV transmission according to maternal HIV-HCV coinfection status and performed sensitivity analyses. RESULTS: Ten articles met our inclusion criteria. Study quality varied widely, and study estimates displayed high statistical heterogeneity. Restriction of the analysis to studies that included >50 HIV-HCV-coinfected women provided our most reliable estimate: maternal HIV-HCV coinfection increases the odds of vertical HCV transmission by ~90% (odds ratio, 1.9; 95% confidence interval, 1.36-2.67), compared with maternal HCV infection alone. When we restricted analyses to HIV-infected mothers with HCV viremia, the odds of vertical HCV transmission were 2.82-fold (95% confidence interval, 1.17-fold to 6.81-fold) greater than the odds for HIV-infected mothers without HCV viremia. CONCLUSIONS: HIV-HCV-coinfected women have significantly higher odds of transmitting HCV to their infants than do women who are infected with HCV alone. (Author' s abstract) |
Domaine : | Hors addiction / No addiction |
Sous-type de document : | Méta-analyse / Meta-analysis ; Revue de la littérature / Literature review |
Refs biblio. : | 29 |
Affiliation : |
Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205. Etats-Unis. United States. |
Centre Emetteur : | 13 OFDT |
Cote : | A03476 |
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