Historique
Article de Périodique
Benzylpiperazine: a drug of abuse? (2007)
(La benzylpipérazine : une drogue synonyme d'abus ?)
Auteur(s) :
A. C. JOHNSTONE ;
R. A. LEA ;
K. A. BRENNAN ;
SCHENK S. ;
M. A. KENNEDY ;
FITZMAURICE P. S.
Article en page(s) :
888-894
Sous-type de document :
Revue de la littérature / Literature review
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
DROGUES DE SYNTHESE
;
MECANISME D'ACTION
;
BZP
;
USAGE RECREATIF
;
METABOLISME
;
PHARMACOLOGIE
;
ABUS
Résumé :
N-benzylpiperazine (BZP) is the active ingredient in recreational 'party' or 'p.e.p.' pills, which are used to provide a stimulant, euphoric effect akin to that of methylenedioxymethamphetamine (MDMA, 'ecstasy'). BZP predominantly affects dopamine neurotransmission in a similar fashion to known 'drugs of abuse', such as methamphetamine and cocaine, which strongly suggests BZP has abuse liability. BZP is illegal in many countries including the United States of America and Australia, yet it remains legal in the United Kingdom, Canada and New Zealand. There has been little research, to date, on the neurological consequences of high dose or chronic exposure of BZP. Here we provide a comprehensive review of the information currently available on BZP and suggest a need for further research into the mechanisms of action, long-term effects and potentially addictive properties of BZP. (Author' s abstract)
Affiliation :
Envirogenomics Group, Institute of Environmental Science and Research Ltd, Porirua.
Nouvelle Zélande. New Zealand.
Nouvelle Zélande. New Zealand.