| Titre : | Substance abuse vaccines |
| Auteurs : | F. M. ORSON ; B. M. KINSEY ; R. A. SINGH ; Y. WU ; T. GARDNER ; T. R. KOSTEN |
| Type de document : | Périodique |
| Année de publication : | 2008 |
| ISBN/ISSN/EAN : | 1749-6632 |
| Format : | 257-269 |
| Note générale : |
Annals of the New York Academy of Sciences, 2008, 1141, 257-269
|
| Langues: | Français |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus mots-clés ANTICORPS ; IMMUNOLOGIE ; VACCINATION ; THEORIE ; COCAINE ; NICOTINE ; MORPHINE ; METHAMPHETAMINE ; PHENCYCLIDINE ; PHARMACOCINETIQUE |
| Résumé : | Conventional substance-abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advanced stages of development. Although several potential mechanisms for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism involves binding of the drug by antibodies in the bloodstream, thereby blocking entry and/or reducing the rate of entry of the drug into the central nervous system. The benefits of such antibodies on drug pharmacodynamics will be influenced by both the quantitative and the qualitative properties of the antibodies. The sum of these effects will determine the success of the clinical applications of antidrug vaccines in addiction medicine. This review will discuss these issues and present the current status of vaccine development for nicotine, cocaine, methamphetamine, phencyclidine, and morphine. (Author' s abstract) |
| Domaine : | Plusieurs produits / Several products |
| Sous-type de document : | Revue de la littérature / Literature review |
| Refs biblio. : | 68 |
| Affiliation : |
Veterans Affairs Medical Center, Houston, TX 77030. Etats-Unis. United States. |
| Centre Emetteur : | 13 OFDT |
| Cote : | A03874 |
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