Titre : | Cocaine use and withdrawal : the effect on sleep and mood |
Titre traduit : | (L'usage de la cocaïne et le sevrage : l'effet sur le sommeil et sur l'humeur) |
Auteurs : | R. WATSON ; L. BAKOS ; P. COMPTON ; GAWIN F. |
Type de document : | Périodique |
Année de publication : | 1992 |
ISBN/ISSN/EAN : | 0095-2990 |
Note générale : |
American Journal of Drug and Alcohol Abuse, 1992, 18, 21-28 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; SOMMEIL ; SEVRAGE ; INHALATION ; MESURES QUANTITATIVES |
Résumé : |
FRANÇAIS : Etude expérimentale sur 3 usagers récréationnels de cocaïne ; privés de cocaïne pendant 48 heures, ayant par la suite sniffé 1 à 2 g de cocaïne, les patients ont régulièrement fait des compte-rendus de leur humeur, ont subi des prises de sang et des mesures physiologiques (EEG, EOG, EMG), y compris pendant leur sommeil. Analyse des résultats. ENGLISH : Three recreational cocaine users (age, 26.7 years), after one adaptation night, spent 5 days and nights in the laboratory where their EEG, EOG, and submental EMG were recorded during all of their sleep. On the second afternoon and evening of the study, subjects used an estimated 1 to 2 g cocaine intranasally. They all slept between 2:00 A.M. and 9.00 A.M. that night. Blood samples were drawn each evening and morning. Absolute plasma cocaine levels and patterns of elimination were consistent with subjects report of dose and time of administration. Mood ratings were made repeatedly throughout the study. There was suppression of REM sleep during the use of cocaine followed by a rebound which is specific to REM sleep and is not seen in other stages of sleep. REM variables subsided to normal levels on the third recovery night following cocaine use. Author's abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 8 |
Affiliation : |
New Haven Sleep Disorders Ctr, 100 York St., New Haven, CT 06511 Etats-Unis. United States. |
Numéro Toxibase : | 501853 |
Centre Emetteur : | 05 Marmottan |
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