Titre : | Effects of GBR 12909 and cocaine on cocaine - maintained behavior in rhesus monkeys |
Titre traduit : | (Effets du GBR 12909 et de la cocaïne sur le comportement de singes rhésus sous cocaïne) |
Auteurs : | SKYJOLDAGER P. ; J. WINGER ; Y. H. WOODS |
Type de document : | Périodique |
Année de publication : | 1993 |
ISBN/ISSN/EAN : | 0376-8716 |
Note générale : |
Drug and Alcohol Dependence , 1993, 33, (1), 31-39 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; MECANISME D'ACTION ; AUTOADMINISTRATION ; COMPORTEMENT ; MODELE ANIMAL |
Résumé : |
FRANÇAIS : Le GBR 12909, inhibiteur de la recapture de la dopamine, semble avoir une efficacité similaire à celle de la cocaïne dans le protocole d'atténuation de l'autoadministration de cocaïne, bien qu'ayant une efficacité directe moindre sur le renforcement. ENGLISH : The reinforcing effect of the high affinity dopamine reuptake inhibitor GBR 12909 (1-[2-[bis(4-fluorophenyl)methoxylethyl]-4(-phenylpropyl) piperazine) was compared with that of cocaine, and the effects of both GBR 12909 and cocaine pretreatments were evaluated on behavior maintained by cocaine in rhesus monkeys. Increasing dose per injection of intravenously-delivered GBR 12909 or cocaine led to increased rates of lever-press responding. Maximum cocaine-maintained rates were higher and occurred at a smaller dose than maximum rates of GBR 12909-maintained responding. Presession intravenous administration of either GBR 12909 or cocaine (0.32, 1.0 or 3.2 mg/kg) resulted in dose-dependent decreases in rates of cocaine-maintained responding when high doses of cocaine, which engendered high response rates, were available early in the session. Under these conditions, the decrease in response rates was associated primarily with decreases in running rate rather than with a lengthening in post-reinforcement pause times. The decreases in running rate produced by both cocaine and GBR 12909 probably reflect an unconditioned rate-disruptive effect of these drugs on cocaine-reinforced responding rather than a reduction in the reinforcing efficacy of cocaine. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 21 |
Affiliation : |
Memphis St. Univ. , Dept Psychol. , Memphis, TN 38152 Etats-Unis. United States. |
Numéro Toxibase : | 801161 |
Centre Emetteur : | 08 CAS Strasbourg |
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