Titre : | Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus |
Titre traduit : | (Facteurs de diminution du taux de lymphocytes CD4+ parmi les toxicomanes intraveineux contaminés par le VIH) |
Auteurs : | P. ALCABES ; E. E. SCHOENBAUM ; R. S. KLEIN |
Type de document : | Périodique |
Année de publication : | 1993 |
ISBN/ISSN/EAN : | 0002-9262E |
Note générale : |
American Journal of Epidemiology, 1993, 137, (9), 989-1000 |
Langues: | Anglais |
Discipline : | EPI (Epidémiologie / Epidemiology) |
Mots-clés : |
Thésaurus mots-clés VOIE INTRAVEINEUSE ; SEROPOSITIVITE ; SIDA ; BACTERIE ; INFECTION ; EPIDEMIOLOGIE |
Résumé : |
FRANÇAIS : De 1985 à 1990, à New York, on a mesuré la perte des lymphocytes CD4 chez 318 toxicomanes intraveineux séropositifs. Dans cette population, le taux de perte moyen des CD4 est de 1,33% sur 6 mois. Les facteurs cliniques prédictifs d'une évolution rapide vers le SIDA sont liés notamment à la présence d'infections bactériennes. ENGLISH : Changes in the level of CD4-bearing T-lymphocytes in injection drug users infected with the human immunodeficiency virus were evaluated in a sample of 318 subjects enrolled from a methadone program in the Bronx, New York, from 1985 through 1989. Follow-up continued through 1990. The percentage of CD4+ T-lymphocytes (CD4%) was used to maximize the stability of measurements. The rate of decline of the CD4% was determined using a random-effects assumption, and predictors of decline was approximately 1.2 CD4% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4% lost). The most important predictors of decline of the CD4% in autoregressive models were current pyogenic bacterial infection (CD4% reduced by 2.75, 95% confidence interval (CI) 0.42-5.08), current report of a second constitutional symptom (CD4% reduced by 2.16, 95% CI 0.03-4.29), and history of bacterial infection (CD4% reduced by 1.49, 95% CI 0.09-2.89; proportion of prior CD4% lost increased by 0.14, 95% CI 0.01-0.27). Oral thrush was not related to an accelerated rate of CD4% decline. (Author's abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 44 |
Affiliation : |
Yales Aids Prog., 495 Congress ave, Welch 2D, New Haven, CT 06519 Etats-Unis. United States. |
Numéro Toxibase : | 101137 |
Centre Emetteur : | 01 Pey Berland |
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