Titre : | Management of substance dependence review series. Systematic review of pharmacological treatment of cocaine dependence |
Auteurs : | OMS / WHO ; WHO, Mental Health and Substance Dependence Department |
Type de document : | Rapport |
Mention d'édition : | WHO/MSD/MSB 00.1 |
Editeur : | Genève : OMS / WHO, 2000 |
Format : | 102 p. / fig. ; tabl. |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; DEPENDANCE ; PHARMACOTHERAPIE ; EVALUATION ; QUALITE DES SOINS ; TRAITEMENTThésaurus géographique INTERNATIONAL |
Résumé : | Cocaine dependence is a common and serious condition, associated with severe medical, psychological and social problems, including the spread of infectious diseases. This series of systematic reviews will critically assess the efficacy of pharmacotherapy for treating cocaine dependence. The literature search strategy included: electronic searches of Cochrane Library holdings, EMBASE, MEDLINE, PsycLIT, Biological Abstracts and LILACS; scans of reference lists of relevant articles, personal communications, conference abstracts, unpublished trials from the pharmaceutical industry and book chapters on the treatment of cocaine dependence. Randomised controlled trials focusing on the use of carbamazepine, antidepressants, dopamine agonists, and other drugs used in the treatment of cocaine dependence were included. Trials in which patients had an additional diagnosis such as opiate dependence were also eligible. The reviewers extracted the data independently, and relative risks (R.R), and weighted mean differences were estimated. Number needed to treat would be calculated for statistically significant outcomes. Qualitative assessments were carried out using a Cochrane validated checklist. Where possible, analysis was carried out according to the "intention to treat" principles. The reviewers assumed that people who died or dropped out had no improvement in their condition. The results indicate that there is no current evidence supporting the clinical use of CBZ, antidepressants, dopamine agonists mazindol, phenytoin, nimodipine, lithium, and NeuRecover-SA, in the treatment of cocaine dependence. Larger randomised investigation must be considered, while taking into account that these time-consuming efforts should be reserved for medications showing more relevant and promising evidence. Given the high dropout rate among the test population, clinicians may wish to consider adding psychotherapeutic supportive measures aimed at keeping patients in treatment programs. (Editor's abstract) |
Texte n° : | WHO/MSD/MSB 00.1 |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 107 |
Numéro Toxibase : | 208037 |
Centre Emetteur : | 02 Coordonnateur |
Lien : | https://apps.who.int/iris/bitstream/handle/10665/66574/WHO_MSD_MSB_00.1.pdf;jsessionid=C44358F4CEECB216A7CA7DE693DC80C0?sequence=1 |
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