Titre : | Cannabis and cannabinoid receptors |
Titre traduit : | (Cannabis et récepteurs cannabinnoïdes.) |
Auteurs : | NOCERINO E. ; M. AMATO ; IZZO A. A. |
Type de document : | Périodique |
Année de publication : | 2000 |
ISBN/ISSN/EAN : | 0367-326X |
Format : | S6-S12 / fig. ; tabl. |
Note générale : |
Fitoterapia, 2000, 71, S6-S12 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés CANNABINOIDES ; RECEPTEUR ; CANNABIS ; EFFET SECONDAIRE ; NEUROBIOLOGIE |
Résumé : |
ENGLISH : Cannabis and cannabinoids exert many of their biological functions through receptor- mediated mechanisms. Two types of cannabinoid receptors have been identified, namely CB1 and CB2, both coupled to a G protein. CB1 receptors have been detected in the central nervous system (where they are responsible for the characteristic effects of cannabis, including catalepsy, depression of motor activity, analgesia and feelings of relaxation and well being) and in peripheral neurons (where their activation produces a suppression in neurotransmitter release in the heart, bladder, intestine and vas deferens). Cannabinoid CB2 receptors have only been detected outside the central nervous system, mostly in cells of the immune system, presumably mediating cannabinoid-induced immunosuppression and antiinflammatory effects. With the discovery of cannabinoid receptors for exogenous cannabinoids, also endogenous cannabinoids (anandamide, 2-arachidonylglycerol) have been described. (Editor' s abstract) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 20 |
Affiliation : |
Dep. Experimental Pharmacology, Univ. Naples "Federico II", via D. Montesano 49, 80131 Naples Italie. Italy. |
Numéro Toxibase : | 205757 |
Centre Emetteur : | 02 Coordonnateur |
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