Titre : | Limits to buprenorphine dosing: a comparison between quintuple and sextuple the maintenance dose every 5 days |
Titre traduit : | (Les limites de l'augmentation de la dose de buprénorphine : comparaison entre une dose de maintenance quintuplée ou sextuplée tous le 5 jours) |
Auteurs : | A. GROSS ; E. A. JACOBS ; N. M. PETRY ; G. J. BADGER ; W. K. BICKEL |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 111-116 |
Note générale : |
Drug and Alcohol Dependence, 2001, 64, (1), 111-116
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés HEROINE ; BUPRENORPHINE ; OPIACES ; DEPENDANCE ; TRAITEMENT DE MAINTENANCE ; SYNDROME DE SEVRAGE ; POSOLOGIE |
Résumé : | The relative efficacy of quintuple and sextuple buprenorphine dosing in abating withdrawal symptoms for 120 h was compared in opioid-dependent outpatients. Fourteen subjects received buprenorphine in a double-blind, placebo-controlled, cross-over design. Daily sublingual maintenance doses were 4 mg/70 kg (n=4) and 8 mg/70 kg (n=10). After a stabilization period of daily maintenance administration, subjects received quintuple (5 x daily maintenance dose) and sextuple (6 x daily maintenance dose) doses every 120 h. Measures of opioid agonist and withdrawal effects were assessed daily. Subjective ratings of withdrawal were significantly greater than baseline ratings beyond 96-h post dosing under both regimens. There was no evidence, however, that those subjective ratings of withdrawal differed between the two regimens. Thus, these data suggest that sextuple buprenorphine dosing, administered every 5 days, does not abate opioid-withdrawal beyond 96 hours. (Author's abstract.) |
Domaine : | Drogues illicites / Illicit drugs |
Affiliation : |
Subst. Abuse Treatm. Ctr., Univ. VT, 1 South Prospect Str., Burlington, VT 05401 Etats-Unis. United States. |
Numéro Toxibase : | 803715 |
Centre Emetteur : | 08 CAS Strasbourg |
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