Titre : | Accelerated withdrawal from methadone maintenance therapy using naltrexone and minimal sedation: a case-series analysis |
Titre traduit : | (Sevrage accéléré de méthadone par la naltrexone et une sédation minimum : analyse de cas) |
Auteurs : | N. J. GLASGOW ; J. TAYLOR ; J. R. BELL ; M. R. YOUNG ; G. BAMMER |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 213-221 |
Note générale : |
Drug and Alcohol Review, 2001, 20, (2), 213-221
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés METHADONE ; NALTREXONE ; TRAITEMENT DE MAINTENANCE ; EFFICACITE ; METHODE |
Résumé : |
FRANÇAIS :
L'objectif de l'étude est d'évaluer le degré d'acceptabilité d'un sevrage de méthadone chez des patients stabilisés, par la naltrexone, le nombre de demandes et le suivi de ces patients sous naltrexone pendant 3 mois. Le protocole a été bien accepté chez les 14 patients étudiés, 4 ont rechuté, mais le rôle de cette forme de maintenance semble toutefois limité. ENGLISH: The aim of this study was to measure the acceptability to stable methadone maintenance clients seeking termination of methadone treatment of accelerated withdrawal using a standardized protocol of naltrexone and minimal sedation; and to provide a first assessment of the probable demand for such treatment, characterize the withdrawal experience, and describe the outcomes for the clients using naltrexone for maintenance therapy for 3 months following withdrawal. We used an open label observational study of 14 stable, methadone maintenance programme clients within the Australian Capital Territory. We found a high degree of acceptability of the withdrawal approach to clients and staff. Three phases of withdrawal identified over a 3-week period. There was rapid attrition from naltrexone maintenance over 3 months of follow-up and a return to dependent opiate use in four clients. The protocol is a humane, effective approach to accelerated withdrawal from methadone maintenance. It is a useful modification to ultra-rapid and other rapid withdrawal techniques. Naltrexone maintenance has a limited potential role in this group of subjects. This role also needs further clarification through well-designed randomized clinical trials. |
Domaine : | Drogues illicites / Illicit drugs |
Affiliation : |
Academic Unit General Practice Community Care, Calvary Hosp., PO Box 254, Jamison Ctr., ACT 2614 Australie. Australia. |
Numéro Toxibase : | 803702 |
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