| Titre : | Effect of opioid dependence pharmacotherapies on Zidovudine disposition |
| Titre original: | (Effet des traitements de la dépendance aux opioïdes sur l'efficacité de la Zidovudine.) |
| Auteurs : | E. F. McCANCE-KATZ ; RAINEY P. M. ; FRIEDLAND G. ; T. R. KOSTEN ; JATLOW P. |
| Type de document : | Périodique |
| Année de publication : | 2001 |
| Format : | 296-307 / graph. ; tabl. |
| Note générale : |
American Journal on Addictions, 2001, 10, (4), 296-307 |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus TOXIBASE LAAM ; ANTIRETROVIRAUX ; BUPRENORPHINE ; NALTREXONE ; INTERACTION CHIMIQUE ; PHARMACOCINETIQUE |
| Résumé : |
ENGLISH : Injection drug users are frequently infected with human immunodeficiency virus (HIV) and receive opioid dependence pharmacotherapies and Zidovudine (ZDV), the latter as a component of highly active antiretroviral therapy. We previously reported that methadone substantially increases ZDV concentrations. We now report on oral ZDV pharmacokinetics in 52 subjects receiving the opioid dependence pharmacotherapies l-alpha-acetylmethadol LAAM, buprenorphine, or naltrexone, and 17 non-opioid-treated controls. Relative to the area under the time-concentration curve (AUC) of ZDV in control subjects, no statistically significant differences in ZDV AUC were observed in participants treated with LAAM (p=.75), buprenorphine (p=.37), or naltrexone (p=.34). While methadone maintenance may result in ZDV toxicity and possibly require dose adjustments, other opioid pharmacotherapies should not produce ZDV toxicity. (Author' s abstract) |
| Note de contenu : | graph. ; tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 29 |
| Affiliation : |
Albert Einstein College of Medicine, Bronx, NY Etats-Unis. United States. |
| Numéro Toxibase : | 205849 |
| Centre Emetteur : | 02 Coordonnateur |
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