Titre : | Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users |
Titre traduit : | (Effets à long terme de la kétamine : persistance des troubles de la mémoire chez les usagers récréatifs) |
Auteurs : | C. J. A. MORGAN ; RICCELLI M. ; C. H. MAITLAND ; H. V. CURRAN |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 301-308 / fig. ; tabl. |
Note générale : | Drug and Alcohol Dependence, 2004, 75, (3), 301-308 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés KETAMINE ; MEMOIRE ; MESUSAGE ; USAGE RECREATIF ; ABUS ; TROUBLES DE LA MEMOIRE ; COGNITION |
Résumé : | Rationale: Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that is increasingly being used as a recreational drug. Previous research has shown gross generalised verbal memory impairments persisting 3 days after ketamine use in chronic users, however episodic memory has not specifically investigated in this population. Objective: To determine whether ketamine, on the night of drug use (day 0) and 3 days later, is associated with impaired episodic memory as assessed by a source memory task. Methods: Twenty ketamine users and 20 poly-drug controls were compared on a source memory task both on day 0 and 3. Participants also completed questionnaires on both days indexing schizophrenic-like and dissociative symptoms. Results: On day 0, ketamine abusers were impaired on both source memory and item recognition and scored more highly on schizophrenic and dissociative symptom scales compared to poly-drug controls. On day 3 ketamine abusers only displayed source memory impairments and these positively correlated with the level of schizophrenic-like symptoms on day 0. No differences on day 3 in schizophrenic-like or dissociative symptoms were observed. Conclusions: Ketamine abusers exhibit a persisting deficit in source memory on day 3 but not in item recognition. These findings suggest that repeated use of ketamine produces chronic impairments to episodic memory. (Review's abstract.) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 43 |
Affiliation : | Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower St., London WC1E 6BT, UK |
Numéro Toxibase : | 804657 |
Centre Emetteur : | 08 CAS Strasbourg |
Exemplaires
Disponibilité |
---|
aucun exemplaire |
Accueil