Titre : | HIV-1 co/super-infection in intravenous drug users |
Titre traduit : | (Co-infection et infection surajoutée par le VIH-1 chez des usagers de drogues par voie intraveineuse.) |
Auteurs : | YERLY S. ; JOST S. ; M. MONNAT ; TELENTI A. ; M. CAVASSINI ; CHAVE J. P. ; KAISER L. ; BURGISSER P. ; L. PERRIN ; The Swiss HIV Cohort Study |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 1413-1421 / fig. ; graph. ; tabl. |
Note générale : |
AIDS, 2004, (18), 1413-1421 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés VIH ; INFECTION ; INJECTION ; PREVALENCE |
Résumé : |
ENGLISH : Background: The frequency of HIV-1 co/super-infection is unknown despite their implications for public health and vaccine development. This issue was addressed during an epidemic of both CRF11 and B subtype among intravenous drug users (IVDUs). Methods: Bulk sequencing of reverse transcriptase, protease and C2V3 regions and subtype-specific nested polymerase chain reaction (PCR) in plasma and proviral DNA were performed using baseline and follow-up samples collected in recently infected IVDUs between 1998-2002 and in IVDUs with chronic infection living in the same area and presenting an unexpected rise of viremia (> 1 log10). Results: In 58 recently infected patients, three B/CRF-11 co-infections, 25 B, 28 CRF- 11 and two other subtypes were detected at baseline. In the three co-infected patients, both CRF-11 and B were detected in plasma and proviral DNA and persisted during follow-up. B- and CFR-11-specific PCR performed on follow-up samples of 40 of 58 recently infected patients (median follow-up, 14.5 months) revealed a transient B super-infection in a patient initially infected by CRF-11. Five of 156 chronic IVDUs (total follow-up: 346 years) had an unexpected rise of viremia. In two of them, aviremic without treatment for years after an initial B infection, a symptomatic CRF-11 super-infection occurred and was associated with high viral load and a fall of CD4 cell count. Conclusions: In recently infected IVDUs, co-infection B/CRF-11 is relatively frequent (5%). In chronically infected IVDUs super-infection may be transient and may occur in patients controlling efficiently HIV infection by the initial strain. (Author' s abstract) |
Note de contenu : | fig. ; graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 26 |
Affiliation : |
Laboratory of Virology, Geneva Univ. Hospital, 1211 Geneva 14. Suisse. Switzerland. |
Numéro Toxibase : | 207880 |
Centre Emetteur : | 02 Coordonnateur |
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