| Titre : | Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence |
| Titre traduit : | (Un traitement de substitution pour l'usage abusif et la dépendance aux stimulants : une pharmacothérapie de type agoniste) |
| Auteurs : | J. GRABOWSKI ; SHEARER J. ; J. MERRILL ; NEGUS S. S. |
| Type de document : | Périodique |
| Année de publication : | 2004 |
| Format : | 1439-1464 / tabl. |
| Note générale : |
Addictive Behaviors, 2004, 29, (7), 1439-1464 |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus TOXIBASE STIMULANTS ; ABUS ; DEPENDANCE ; SUBSTITUTION ; AGONISTE |
| Résumé : |
ENGLISH : Stimulant abuse and dependence are disproportionately problematic due to the combination of legal and social issues added to the serious behavioural and biological features of the disorders. These problems are compounded by adverse consequences for families and society. Illegality and stigma multiply the consequences of use and difficulties in providing treatment. Specific behavioural interventions have been demonstrated as useful in treatment of substance use disorders (SUDs). Medications also have an important role in treatment. Effective agonist and antagonist pharmacotherapies as well as symptomatic treatments exist for opioid and nicotine dependence. Neither agonists nor antagonists have been approved as uniquely effective for treatment of stimulant abuse or dependence. Still, promising results are emerging for an agonist-like or 'replacement' strategy paralleling that for nicotine and opioid dependence. Supporting data have emerged from both preclinical and clinical research environments. There are scientific, clinical, social, and legal impediments to application of an agonist-like approach to stimulant abuse and dependence. Some resemble past and current concerns about opioid replacement. Others are unique to the stimulant agents, effects, and clinical features. Here, the authors consider (1) agonist and antagonist pharmacotherapy strategies; (2) preclinical research, including methodological approaches, opioid and nicotine replacement, and agonists for stimulant dependence; (3) clinical reports with stimulant medications in cocaine dependence, and the amphetamine replacement strategy for amphetamine dependence; (4) application of agonist-like/replacement strategies, including clinical requirements and risks; and (5) directions for research. (Editor's abstract.) |
| Note de contenu : | tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 119 |
| Affiliation : |
Substance Abuse Research Center, Department of Psychiatry and Behavioural Sciences, University of Texas-Health Science Center at Houston, 1300 Moursund Street, Houston TX 77030. E-mail : john.grabowskiuth.tmc.edu Etats-Unis. United States. |
| Numéro Toxibase : | 404592 |
| Centre Emetteur : | 04 CIRDD-51 |
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