Titre : | The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program : a randomized, double blind, placebo controlled, prospective study |
Titre traduit : | (Effet de l'administration d'un complément de "mianserin" sur l'intensité des symptômes de sevrage d'opiacés pendant une cure de désintoxication. Une étude prospective, randomnisée, en double aveugle, contrôlée par placebo) |
Auteurs : | I. HERMAN ; SHAMIR D. ; R. BAR-HAMBURGER ; PICK C. G. ; SCHREIBER S. |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 1154-1167 / graph. ; tabl. |
Note générale : |
Addictive Behaviors, 2005, 30, (6), 1154-1167 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés CURE DE DESINTOXICATION ; OPIACES ; SYNDROME DE SEVRAGE ; MEDICAMENTS ; EFFICACITE ; ETUDE PROSPECTIVE ; PLACEBO |
Résumé : |
ENGLISH : Background Based on pre-clinical studies regarding the interaction of various antidepressant drugs with the opioid system, we designed a clinical study to be carried out in the in-patient detoxification unit within a large community centre for treatment of drugs dependent people. We evaluated the effect of mianserin add-on, on the intensity of opioid withdrawal symptoms in opiate dependent subjects undergoing medication-supported physical detoxification and integrated psychosocial and psychotherapeutic intervention for the treatment of dependence. Methods Mianserin (or placebo) was added to the routine medication protocol, during the 3-week in-patient phase of detoxification in a prospective, randomized, double blind, placebo controlled study. Mianserin (or placebo) was continued after discharge and patients were followed up for 3 months in order to evaluate relapse rates. Opiate withdrawal symptoms were assessed during the first 10 days, while depression and anxiety were assessed throughout the 3 months of study. Results From day 2 onward, patients in the study group showed significantly lower withdrawal symptoms than the control group patients and reached this peak faster (study group 2.8 days, control group 3.2 days, p |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 34 |
Affiliation : |
Jaffa Centre for the Treatment of Drug Victims and Tel Aviv University Sackler School of Medicine, Tel Aviv. E-mail : shaulschtasmc.health.gov.il Israël. Israel. |
Numéro Toxibase : | 404947 |
Centre Emetteur : | 04 CIRDD-51 |
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