Historique
Périodique
Use of slow-release oral morphine for the treatment of opioid dependence
(Utilisation de la morphine retard par voie orale dans le traitement de la dépendance aux opiacés)
Auteur(s) :
D. KRAIGHER ;
R. JAGSCH ;
GOMBAS W. ;
R. ORTNER ;
H. EDER ;
A. PRIMORAC ;
G. FISCHER
Article en page(s) :
145-151
Refs biblio. :
50
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Thésaurus mots-clés
MORPHINE
;
DISTRIBUTION CONTROLEE
;
TRAITEMENT DE MAINTENANCE
;
VOIE ORALE
;
EFFICACITE
;
OPIOIDES
Thésaurus géographique
AUTRICHE
Note générale :
European Addiction Research, 2005, 11, (3), 145-151
Résumé :
Aims: In addition to methadone, other synthetic opioids are now available for the treatment of opioid dependence. The study investigated the treatment satisfaction of oral slow-release morphine for maintenance therapy in opioid-dependent patients in an open-label 3-week study. Design: We evaluated the treatment satisfaction of oral slow-release morphine hydrochloride for 3 weeks in 110 patients meeting the diagnosis of opioid dependence (DSM-IV 304.0) or polysubstance dependence (DSM-IV 304.9). Measurements: Primary outcome measures were the study retention rate, urinalysis for additional illicit consumption other than heroin, cravings and withdrawal symptoms 24 h after the last intake of the medication (duration of action of treatment). Findings: In total, 103 patients completed the study, representing a retention rate of 94%. Patients reported significant improvements in somatic complaints, as well as significant reductions in heroin and cocaine cravings (p
Affiliation :
Addiction Clinic, Department of General Psychiatry, University Hospital of Vienna, Vienna, Austria
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