Titre : | Matching of treatment-resistant heroin-dependent patients to medical prescription of heroin or oral methadone treatment: results from two randomized controlled trials |
Titre traduit : | (Orientation adéquate de patients héroïnomanes résistant au traitement vers une prescription d'héroïne ou de méthadone orale : résultats de deux essais contrôlés randomisés.) |
Auteurs : | P. BLANKEN ; V. M. HENDRIKS ; M. W. J. KOETER ; J. M. VAN REE ; W. VAN DEN BRINK |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 89-95 / tabl. |
Note générale : |
Addiction, 2005, 100, (1), 89-95 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés TRAITEMENT DE MAINTENANCE ; METHADONE ; HEROINE ; DISTRIBUTION CONTROLEE ; EFFICACITE ; COMPARAISON ; ETUDE LONGITUDINALEThésaurus géographique PAYS-BAS |
Résumé : |
FRANÇAIS : Comparaison sur 12 mois chez 430 héroïnomanes dun traitement méthadone seul (150 mg/jour) et dun traitement méthadone associé à de lhéroïne injectable ou inhalée (1000 mg/jour). La prescription médicale dhéroïne est plus efficace chez les patients qui déjà participé à un traitement orienté vers labstinence. ENGLISH : Aims To investigate which baseline patient characteristics of treatment-resistant heroin addicts differentially predicted treatment response to medical heroin prescription compared to standard methadone maintenance treatment. Design Two open-label randomized controlled trials; pooled data. Setting Methadone maintenance programmes and heroin treatment centres in six cities in the Netherlands. Participants Four hundred and thirty heroin addicts. Intervention Methadone plus injectable heroin or methadone plus inhalable heroin compared to methadone alone prescribed over 12 months: heroin maximum 1000 mg per day, methadone maximum 150 mg per day. Main outcome measure Dichotomous, multi-domain response index, including validated indicators of physical health, mental status and social functioning. Findings Data of the inhalable and injectable heroin trials were pooled. Intention-to-treat analysis showed that treatment with medically prescribed heroin plus methadone was significantly more effective (51.8% response) than standard methadone maintenance treatment (28.7%) (95% CI of response difference: 14.1 - 32.2%). Multivariate logistic regression analyses showed that only one of all baseline characteristics was predictive of a differential treatment effect: patients who had previously participated in abstinence-orientated treatment responded significantly better to heroin-assisted treatment than to methadone treatment (61% versus 24%), while patients without experience in abstinence-orientated treatment did equally well in heroin-assisted or methadone maintenance treatment (39% and 38%, respectively). Conclusions The effect of heroin-assisted treatment is not dependent on clinical characteristics, with the exception of previous abstinence-orientated treatment: medical prescription of heroin is most effective for those patients who have previously participated in abstinence-orientated treatment. (Author' s abstract) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 21 |
Affiliation : |
Central Committee on the Treatment of Heroin Addicts (CCBH), Univ. Medical Centre Utrecht, Stratenum 5th Floof, Universiteitsweg 100, 3584 CG Utrecht. E-mail: p.blanken@med.uu.nl Pays-Bas. Netherlands. |
Numéro Toxibase : | 208177 |
Centre Emetteur : | 02 Coordonnateur |
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