Titre : | Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study |
Titre traduit : | (Méthadone versus buprénorphine chez des femmes enceintes dépendantes : une étude comparative en double aveugle.) une pilote prospective randomisée en double aveugle |
Auteurs : | G. FISCHER ; R. ORTNER ; K. ROHRMEISTER ; R. JAGSCH ; A. BAEWERT ; M. LANGER ; H. ASCHAUER |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 275-281 / tabl. |
Note générale : |
Addiction, 2006, 101, (2), 275-281, tabl.
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés METHADONE ; BUPRENORPHINE ; GROSSESSE ; OBSERVANCE DU TRAITEMENT ; RETENTION ; ABSTINENCE ; SYNDROME DE SEVRAGE ; COMPARAISON |
Résumé : | Aims: To evaluate the efficacy and safety of methadone versus buprenorphine treatment in pregnant opioid-dependent women. Design: Randomized, double-dummy, double-blind, flexible-dosing comparison study. Setting: Addiction Clinic at the Medical University of Vienna, Austria. Participants: Eighteen women were assigned randomly to receive either methadone (n = 9) or buprenorphine (n = 9) during weeks 2429 of pregnancy. After dropouts, data were available from 14 cases (six in the methadone and eight in the buprenorphine group). Intervention: Sublingual buprenorphine tablets (824 mg/day) or oral methadone solution (40100 mg/day), with matched placebos. Measurements: Mothers: retention in treatment, urine toxicology and nicotine use. Neonates: Routine birth data, neonatal abstinence syndrome (NAS) in severity and duration. Findings: There was somewhat greater retention in the buprenorphine group but significantly lowered use of additional opioids in the methadone group (P = 0.047).Neonates: There was earlier onset of NAS in neonates born to the methadone (mean 60 hours) than to the buprenorphine groups (mean 72 hours after last medication); 43% did not require NAS-treatment with short treatment duration in both groups (mean 5 days). Conclusion: This preliminary study had limited power to detect differences but the trends observed suggest this kind of research is practicable and that further studies are warranted. (Review' s abstract) |
Domaine : | Autres substances / Other substances ; Drogues illicites / Illicit drugs |
Refs biblio. : | 33 |
Affiliation : |
Addiction Clinic, Department of Psychiatry, Medical University of Vienna, Währinger Gürtel 1820, 1090 Vienna, Australie. Australia. |
Numéro Toxibase : | 208798 |
Centre Emetteur : | 02 Coordonnateur |
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