[article] | Titre : |
4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-DMAR, 4,4'-dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity |
| Type de document : |
Périodique |
| Auteurs : |
J. GLANVILLE ; P. I. DARGAN ; D. M. WOOD |
| Année de publication : |
2015 |
| Article en page(s) : |
193-198 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Thésaurus TOXIBASE
DROGUES DE SYNTHESE ; TOXICITE ; INTERNET ; PRIX ; DIFFUSION DES PRODUITS ; PREVALENCE ; TYPE D'USAGE ; EFFET SECONDAIRE
|
| Discipline : |
PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods |
| Résumé : |
Objective: 4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-dimethylaminorex (4,4'-DMAR)) is a derivative of the controlled substances aminorex and 4-methylaminorex marketed as a potential novel psychoactive substance. This paper brings together the published scientific and 'grey' literature to understand 4,4'-DMAR as a novel psychoactive substance.
Methods: Searches of the published scientific and 'grey' literature, using the keywords '4-methyl-euphoria', '4-methyl-U4Euh', '4-M-4-MAR', '4,4-dimethylaminorex', '4,4'-DMAR', 'para-methyl-4-aminorex' and 'Serotoni', were undertaken to identify information on the availability, prevalence of use and desired/unwanted effects of 4,4'-DMAR.
Results: No studies have reported the prevalence of use of 4,4'-DMAR. Internet snapshot studies in April and May 2014 showed availability of 4,4'-DMAR from one and two Internet suppliers respectively. Price decreased with increasing purchase amounts from €12/g for a 1-g purchase to €2.20/g for a 100-g purchase in April 2014. Internet discussion fora suggest that the desired and unwanted effects of 4,4'-DMAR are similar to those seen with other sympathomimetic drugs such as 3,4-methylenedioxy-methamphetamine and mephedrone, although the duration of unwanted effects and 'comedown' appear to be longer. Unwanted effects were reported at doses of 5-200 mg, which overlaps with the reported doses (10-200 mg) associated with desired effects. 4,4'-DMAR has been detected, along with other drugs, in 27 deaths in Europe; the contribution of the 4,4'-DMAR in these deaths has not been established.
Conclusions: Currently, there appears to limited availability of 4,4'-DMAR; therefore, use is likely to be low. Its desired and unwanted effects appear similar to other sympathomimetic recreational drugs such as methylenedioxy-methamphetamine or mephedrone. Copyright © 2015 John Wiley & Sons, Ltd. |
| Domaine : |
Drogues illicites / Illicit drugs |
| Sous-type de document : |
Revue de la littérature / Literature review |
| Affiliation : |
Clinical Toxicology, St Thomas' Hospital, London, UK |
| Permalink : |
https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=76043 |
in Human Psychopharmacology: Clinical and Experimental > Vol.30, n°3 (May 2015) . - 193-198
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4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-DMAR, 4,4'-dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity in Human Psychopharmacology: Clinical and Experimental, Vol.30, n°3 (May 2015)
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