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Auteur M. J. THUN
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50-Year trends in smoking-related mortality in the United States / M. J. THUN ; B. D. CARTER ; D. FESKANICH ; N. D. FREEDMAN ; R. PRENTICE ; A. LOPEZ ; P. HARTGE ; S. M. GAPSTUR in New England Journal of Medicine, Vol.368, n°4 (January 24, 2013)
Titre : 50-Year trends in smoking-related mortality in the United States Type de document : Périodique Auteurs : M. J. THUN ; B. D. CARTER ; D. FESKANICH ; N. D. FREEDMAN ; R. PRENTICE ; A. LOPEZ ; P. HARTGE ; S. M. GAPSTUR Année de publication : 2013 Article en page(s) : 351-364 Note générale : Editorial: New evidence that cigarette smoking remains the most important health hazard. Schroeder S.A., p. 389-390.
Correspondence: Smoking-Related Mortality in the United States. Lippi G., Mattiuzzi C., Cerimele J.M., Halperin A.C., Blum A., Thun M.J., Lopez A.D., Hartge P., Schroeder S., NEJM 2013;368(18), p. 1752-1754.
Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
TABAC ; MORTALITE ; EVOLUTION ; COHORTE ; FACTEUR DE RISQUE ; CAUSE DE DECES ; SEXE ; AGE
Discipline : EPI Epidémiologie / Epidemiology Résumé : Background: The disease risks from cigarette smoking increased in the United States over most of the 20th century, first among male smokers and later among female smokers. Whether these risks have continued to increase during the past 20 years is unclear. Methods: We measured temporal trends in mortality across three time periods (1959-1965, 1982-1988, and 2000-2010), comparing absolute and relative risks according to sex and self-reported smoking status in two historical cohort studies and in five pooled contemporary cohort studies, among participants who became 55 years of age or older during follow-up.
Results: For women who were current smokers, as compared with women who had never smoked, the relative risks of death from lung cancer were 2.73, 12.65, and 25.66 in the 1960s, 1980s, and contemporary cohorts, respectively; corresponding relative risks for male current smokers, as compared with men who had never smoked, were 12.22, 23.81, and 24.97. In the contemporary cohorts, male and female current smokers also had similar relative risks for death from chronic obstructive pulmonary disease (COPD) (25.61 for men and 22.35 for women), ischemic heart disease (2.50 for men and 2.86 for women), any type of stroke (1.92 for men and 2.10 for women), and all causes combined (2.80 for men and 2.76 for women). Mortality from COPD among male smokers continued to increase in the contemporary cohorts in nearly all the age groups represented in the study and within each stratum of duration and intensity of smoking. Among men 55 to 74 years of age and women 60 to 74 years of age, all-cause mortality was at least three times as high among current smokers as among those who had never smoked. Smoking cessation at any age dramatically reduced death rates.
Conclusions: The risk of death from cigarette smoking continues to increase among women and the increased risks are now nearly identical for men and women, as compared with persons who have never smoked. Among men, the risks associated with smoking have plateaued at the high levels seen in the 1980s, except for a continuing, unexplained increase in mortality from COPD.
Domaine : Tabac / Tobacco Refs biblio. : 36 Affiliation : Department of Epidemiology, American Cancer Society, Atlanta, GA, USA Lien : http://dx.doi.org/10.1056/NEJMsa1211127 Permalink :
in New England Journal of Medicine > Vol.368, n°4 (January 24, 2013) . - 351-364[article]Alcohol consumption and mortality among middle-aged and elderly U.S. adults / M. J. THUN in New England Journal of Medicine, Vol.337, n°24 (December 11, 1997)
Titre : Alcohol consumption and mortality among middle-aged and elderly U.S. adults Type de document : Périodique Auteurs : M. J. THUN ; R. PETO ; A. D. LOPEZ ; J. H. MONACO ; S. J. HENLEY ; HEATH ; J. R. C. W. ; R. DOLL Année de publication : 1997 Article en page(s) : 1705-1714 Présentation : graph. Note générale : • Editorial: "Hazards and benefits of alcohol", p. 1763-1764, J.D. Potter
• Letter to the Editor + Author's reply: NEJM, 1998; 338(19):1385-6.
Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
ETUDE PROSPECTIVE ; EPIDEMIOLOGIE ; ALCOOL ; DEPENDANCE ; MORTALITE ; USAGE REGULIER ; CONSOMMATION ; PERSONNE AGEE ; ADULTE ; CIRRHOSE ; CANCER ; APPAREIL CARDIOVASCULAIRE ; TABAC ; COMPARAISON
Discipline : EPI Epidémiologie / Epidemiology Résumé : Background - Alcohol consumption has both adverse and beneficial effects on survival. We examined the balance of these in a large prospective study of mortality among U.S. adults.
Methods - Of 490, 000 men and women (mean age, 56 years; range, 30 to 104) who reported their alcohol and tobacco use in 1982, 46,000 died during nine years of follow-up. We compared cause-specific death rates and rates of death from all causes across categories of base-line alcohol consumption, adjusting for other risk factors, and related drinking and smoking habits to the cumulative probability of dying between the ages of 35 and 69 years.
Results - Causes of death associated with drinking were cirrhosis and alcoholism; cancers of the mouth, oesophagus, pharynx, larynx, and liver combined; breast cancer in women; and injuries and other external causes in men. The mortality from breast cancer was 30 percent higher among women reporting at least one drink daily than among nondrinkers (relative risk, 1.3; 95 percent confidence interval, 1.1 to 1.6). The rates of death from all cardiovascular diseases were 30 to 40 percent lower among men (relative risk, 0.7; 95 percent confidence interval, 0.7 to 0.8) and women (relative risk, 0.6; 95 percent confidence interval, 0.6 to 0.7) reporting at least one drink daily than among nondrinkers, with little relation to the level of consumption. The overall death rates were lowest among men and women reporting about one drink daily. Mortality from all causes increased with heavier drinking, particularly among adults under age 60 with lower risk of cardiovascular disease. Alcohol consumption was associated with a small reduction in the overall risk of death in middle age (ages 35 to 69), whereas smoking approximately doubled this risk.
Conclusions - In this middle-aged and elderly population, moderate alcohol consumption slightly reduced overall mortality. The benefit depended in part on age and background cardiovascular risk and was far smaller than the large increase in risk produced by tobacco.
Domaine : Alcool / Alcohol Refs biblio. : 38 Affiliation : Epidemiology and Surveillance Research, American Cancer Society, Atlanta / Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, England / Programme on Substance Abuse, WHO, Geneva
Centre Emetteur : 13 OFDT Lien : https://doi.org/10.1056/NEJM199712113372401 Permalink :
in New England Journal of Medicine > Vol.337, n°24 (December 11, 1997) . - 1705-1714[article]Cigarette tar yields in relation to mortality from lung cancer in the cancer prevention study II prospective cohort, 1982-8 / J. E. HARRIS
Titre : Cigarette tar yields in relation to mortality from lung cancer in the cancer prevention study II prospective cohort, 1982-8 Type de document : Périodique Auteurs : J. E. HARRIS ; M. J. THUN ; MONDUL A. M. ; CALLE E. E. Année de publication : 2004 Importance : 72-79 Présentation : tabl. Note générale : British Medical Journal, 2004, 328, (7431), 72-79 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
FACTEUR DE RISQUE ; CANCER ; POUMON ; TABAC ; CIGARETTE ; GOUDRONS ; MORTALITE ; EPIDEMIOLOGIE
Discipline : EPI Epidémiologie / Epidemiology Résumé :
Objective. To assess the risk of lung cancer in smokers of medium tar filter cigarettes compared with smokers of low tar and very low tar filter cigarettes. Design. Analysis of the association between the tar rating of the brand of cigarette smoked in 1982 and mortality from lung cancer over the next six years. Multivariate proportional hazards analyses used to assess hazard ratios, with adjustment for age at enrolment, race, educational level, marital status, blue collar employment, occupational exposure to asbestos, intake of vegetables, citrus fruits, and vitamins, and, in analyses of current and former smokers, for age when they started to smoke and number of cigarettes smoked per day. Setting. Cancer prevention study II (CPS-II). Participants. 364 239 men and 576 535 women, aged 30 years, who had either never smoked, were former smokers, or were currently smoking a specific brand of cigarette when they were enrolled in the cancer prevention study. Main outcome measure. Death from primary cancer of the lung among participants who had never smoked, former smokers, smokers of very low tar (7 mg tar/cigarette) filter, low tar (8-14 mg) filter, high tar (22 mg) non-filter brands and medium tar conventional filter brands (15-21 mg). Results. Irrespective of the tar level of their current brand, all current smokers had a far greater risk of lung cancer than people who had stopped smoking or had never smoked. Compared with smokers of medium tar (15-21 mg) filter cigarettes, risk was higher among men and women who smoked high tar (22 mg) non-filter brands (hazard ratio 1.44, 95% confidence interval 1.20 to 1.73, and 1.64, 1.26 to 2.15, respectively). There was no difference in risk among men who smoked brands rated as very low tar (1.17, 0.95 to 1.45) or low tar (1.02, 0.90 to 1.16) compared with those who smoked medium tar brands. The same was seen for women (0.98, 0.80 to 1.21, and 0.95, 0.82 to 1.11, respectively). Conclusion. The increase in lung cancer risk is similar in people who smoke medium tar cigarettes (15-21 mg), low tar cigarettes (8-14 mg), or very low tar cigarettes (7 mg). Men and women who smoke non-filtered cigarettes with tar ratings 22 mg have an even higher risk of lung cancer. (Review' s abstract)
Note de contenu : tabl. Domaine : Tabac / Tobacco Refs biblio. : 72 Affiliation : Dpt of Economics, Massachusetts Institute of Technology, Cambridge MA 02139
Etats-Unis. United States.
Centre Emetteur : 13 OFDT Cote : A01595 Permalink : How much of the decrease in cancer death rates in the United States is attributable to reductions in tobacco smoking? / M. J. THUN in Tobacco Control, Vol.15, n°5 (October 2006)
Titre : How much of the decrease in cancer death rates in the United States is attributable to reductions in tobacco smoking? Type de document : Périodique Auteurs : M. J. THUN ; JEMAL A. Année de publication : 2006 Article en page(s) : 345-347 Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
TABAC ; CANCER ; MORTALITE ; EVOLUTION
Discipline : EPI Epidémiologie / Epidemiology Résumé : Reductions in tobacco smoking are a major factor in the decrease in cancer mortality rates. Domaine : Tabac / Tobacco Sous-type de document : Editorial Refs biblio. : 9 Affiliation : Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA, USA Centre Emetteur : 13 OFDT Cote : A02892 Lien : http://dx.doi.org/10.1136/tc.2006.017749 Permalink :
in Tobacco Control > Vol.15, n°5 (October 2006) . - 345-347[article]Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies / M. J. THUN ; L. M. HANNAN ; L. L. ADAMS-CAMPBELL ; P. BOFFETTA ; J. E. BURING ; D. FESKANICH ; W. D. FLANDERS ; S. H. JEE ; K. KATANODA ; L. N. KOLONEL ; I. M. LEE ; T. MARUGAME ; J. R. PALMER ; E. RIBOLI ; T. SOBUE ; E. AVILA TANG ; L. R. WILKENS ; J. M. SAMET in PLoS Medicine, Vol.5, n°9 (September 2008)
Titre : Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies Type de document : Périodique Auteurs : M. J. THUN ; L. M. HANNAN ; L. L. ADAMS-CAMPBELL ; P. BOFFETTA ; J. E. BURING ; D. FESKANICH ; W. D. FLANDERS ; S. H. JEE ; K. KATANODA ; L. N. KOLONEL ; I. M. LEE ; T. MARUGAME ; J. R. PALMER ; E. RIBOLI ; T. SOBUE ; E. AVILA TANG ; L. R. WILKENS ; J. M. SAMET Année de publication : 2008 Article en page(s) : e185 ; 15 p. Langues : Anglais (eng) Mots-clés : Thésaurus TOXIBASE
POUMON ; CANCER ; NON FUMEUR ; COHORTE ; COMPARAISON ; TABAC ; FUMEUR ; MORTALITE ; INCIDENCE
Discipline : PAT Pathologie organique / Organic pathology Résumé : BACKGROUND: Better information on lung cancer occurrence in lifelong nonsmokers is needed to understand gender and racial disparities and to examine how factors other than active smoking influence risk in different time periods and geographic regions.
METHODS AND FINDINGS: We pooled information on lung cancer incidence and/or death rates among self-reported never-smokers from 13 large cohort studies, representing over 630,000 and 1.8 million persons for incidence and mortality, respectively. We also abstracted population-based data for women from 22 cancer registries and ten countries in time periods and geographic regions where few women smoked. Our main findings were: (1) Men had higher death rates from lung cancer than women in all age and racial groups studied; (2) male and female incidence rates were similar when standardized across all ages 40+ y, albeit with some variation by age; (3) African Americans and Asians living in Korea and Japan (but not in the US) had higher death rates from lung cancer than individuals of European descent; (4) no temporal trends were seen when comparing incidence and death rates among US women age 40-69 y during the 1930s to contemporary populations where few women smoke, or in temporal comparisons of never-smokers in two large American Cancer Society cohorts from 1959 to 2004; and (5) lung cancer incidence rates were higher and more variable among women in East Asia than in other geographic areas with low female smoking.
CONCLUSIONS: These comprehensive analyses support claims that the death rate from lung cancer among never-smokers is higher in men than in women, and in African Americans and Asians residing in Asia than in individuals of European descent, but contradict assertions that risk is increasing or that women have a higher incidence rate than men. Further research is needed on the high and variable lung cancer rates among women in Pacific Rim countries.
Domaine : Hors addiction / No addiction ; Tabac / Tobacco Refs biblio. : 71 Affiliation : American Cancer Society, Atlanta, Georgia, USA Lien : http://dx.doi.org/10.1371/journal.pmed.0050185 Permalink :
in PLoS Medicine > Vol.5, n°9 (September 2008) . - e185 ; 15 p.[article]Smoking and mortality - Beyond established causes / B. D. CARTER ; C. C. ABNET ; D. FESKANICH ; N. D. FREEDMAN ; P. HARTGE ; C. E. LEWIS ; J. K. OCKENE ; R. L. PRENTICE ; F. E. SPEIZER ; M. J. THUN ; E. J. JACOBS in New England Journal of Medicine, Vol.372, n°7 (February 12, 2015)Permalink