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Auteur G. LE ROUX
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A 6-year review of new psychoactive substances at the Centre antipoison Grand-Ouest d'Angers: Clinical and biological data / A. TURCANT ; M. DEGUIGNE ; S. FÉREC ; C. BRUNEAU ; I. LEBORGNE ; B. LELIÈVRE ; C. GEGU ; F. JEGOU ; C. ABBARA ; G. LE ROUX ; D. BOELS in Toxicologie Analytique et Clinique, Vol.29, n°1 (Février 2017)
Titre : A 6-year review of new psychoactive substances at the Centre antipoison Grand-Ouest d'Angers: Clinical and biological data Type de document : Périodique Auteurs : A. TURCANT ; M. DEGUIGNE ; S. FÉREC ; C. BRUNEAU ; I. LEBORGNE ; B. LELIÈVRE ; C. GEGU ; F. JEGOU ; C. ABBARA ; G. LE ROUX ; D. BOELS Année de publication : 2017 Article en page(s) : 18-33 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
DROGUES DE SYNTHESE ; PHENOMENE EMERGENT ; DEPISTAGE ; TOXICOLOGIE ; CATHINONE ; EFFET SECONDAIRE ; KETAMINE ; ETUDE DE CAS ; CANNABINOIDES ; ANALYSE CHIMIQUE
Discipline : PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods Résumé : For the last 10 years, recreational use of new psychoactive substances (NPS) with hallucinogenic properties was more and more described either in a context of consumption during a rave-party or at home alone or in small group. A review of 62 cases (56 M, 6 F, 16-46 y) registered from 2011 to 2016 at the French Grand Ouest centre antipoison of Angers is presented. Some of them (n = 15) presented a severe clinical state (poison severity score, PSS = 3) and only one was a fatal intoxication (PSS = 4). Treatment of acute intoxication was mainly based on supportive care with a quick recovery in less than 48 h. A high number of these cases were documented by plasma (pl) and/or urine analyses using LC-UV, GC-MS and LC-MS². Several powders or other forms bought on the web market by the patients were also analysed. Six amphetamines derivates were detected such as methiopropamine (pl: 50 - 430 µg/L, n = 6) or 5 others (6-APB, 6-APDB, 5-EAPB, 5-MAPB, 2-FA each once). Four 2,5-dimethoxy-derivates of phenylethylamines (2Cs) or of amphetamines (DOs) were detected as 2C-P (pl: Domaine : Autres substances / Other substances ; Drogues illicites / Illicit drugs Refs biblio. : 48 Affiliation : Laboratoire de pharmacologie-toxicologie, institut de biologie en santé, CHU d’Angers, Angers, France Cote : Abonnement Lien : http://www.sciencedirect.com/science/journal/23520078/29/1 Permalink :
in Toxicologie Analytique et Clinique > Vol.29, n°1 (Février 2017) . - 18-33[article]Recreational phenethylamine poisonings reported to a French poison control center / G. LE ROUX ; C. BRUNEAU ; B. LELIÈVRE ; M. BRETAUDEAU DEGUIGNE ; A. TURCANT ; P. HARRY ; D. BOELS in Drug and Alcohol Dependence, Vol.154 (September 2015)
Titre : Recreational phenethylamine poisonings reported to a French poison control center Type de document : Périodique Auteurs : G. LE ROUX ; C. BRUNEAU ; B. LELIÈVRE ; M. BRETAUDEAU DEGUIGNE ; A. TURCANT ; P. HARRY ; D. BOELS Année de publication : 2015 Article en page(s) : 46-53 Langues : Anglais (eng) Mots-clés : Thésaurus Géographique
DROGUES DE SYNTHESE ; USAGE RECREATIF ; INTOXICATION ; ETUDE DE CAS ; ECSTASY ; AMPHETAMINES ; METHAMPHETAMINE ; TOXICOLOGIE ; EFFET SECONDAIRE ; SYMPTOME ; ANALYSE CHIMIQUE
Mots-clés : centre antipoison Discipline : PRO Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods Résumé : Objectives Over the last decade, use of phenethylamines has become increasingly prevalent. This study aimed to describe typical aspects of phenethylamine poisoning in order to better inform patient care.
Methods: Phenethylamine poisoning cases reported to the Poison Control Center of Angers, France, from January, 2007 to December, 2013 were examined. Clinical findings were examined in 105 patients, including phenethylamine used, symptoms and final outcome. Patients were predominantly male (80%), with mean age 26 ± 8 years.
Results: MDMA (38%), amphetamine (18%) and methamphetamine (14%) were the most commonly reported. Synthetic cathinones (10%) and the 2C series (7%) were also found. Substances most commonly associated with phenethylamine poisoning were cannabis (27%), ethanol (20%) and cocaine (9%). The most frequently reported symptoms included anxiety and hallucinations (49%), mydriasis and headache (41%), tachycardia (40%) and hypertension (15%). Complications such as seizures (7%), cardiac arrest (5%), toxic myocarditis (1%) and hemorrhagic stroke (1%) were also observed. Of the cases, the Poison Severity Score was: null or low, 66%, moderate, 21%, severe or fatal, 13%. Of the patients, 77% received hospital care and 12.4% were admitted to an intensive care unit. Analytical confirmations were obtained for all severe cases. While 93% of patients recovered, there were 5 deaths and 2 patients presented with neurological sequelae.
Conclusions: Phenethylamine poisonings may be severe in young and healthy individuals. Physicians, toxicologists and analysts should be aware of new phenethylamine consumption trends in order to inform management of patient care and to contribute to a more responsive drug policy.
We analyzed 105 cases of phenethylamine poisoning reported to our poison control center.
MDMA, amphetamine and methamphetamine were the most represented drugs.
Psychiatric, cardiovascular or neurological disorders were the most frequent symptoms.
Toxicological confirmation was performed in more than half of patients.
Exposure was severe in nine cases and fatal in five cases.
Domaine : Drogues illicites / Illicit drugs Sous-type de document : Etude de cas / Case report Affiliation : CHU d'Angers, Poison Control Center Angers University Hospital, Poison Control Center, Angers, France Permalink :
in Drug and Alcohol Dependence > Vol.154 (September 2015) . - 46-53[article]