Repeated subcutaneous administrations of krokodil causes skin necrosis and internal organs toxicity in Wistar rats: putative human implications

E. A. ALVES ; P. BRANDAO ; J. F. NEVES ; S. M. CRAVO ; J. X. SOARES ; J. P. C. GRUND ; J. A. DUARTE ; C. M. M. AFONSO ; A. D. PEREIRA NETTO ; F. CARVALHO ; R. J. DINIS-OLIVEIRA | 2017
Dans Human Psychopharmacology: Clinical and Experimental (Vol.32, n°3, May 2017) Article : Périodique

Objective: "Krokodil" is the street name for an impure homemade drug mixture used as a cheap substitute for heroin, containing desomorphine as the main opioid. Abscesses, gangrene, thrombophlebitis, limb ulceration and amputations, jaw osteonecr[...]

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The harmful chemistry behind krokodil (desomorphine) synthesis and mechanisms of toxicity

E. AMORIM ALVES ; J. P. CORNELIS GRUND ; C. M. AFONSO ; A. D. PEREIRA NETTO ; F. CARVALHO ; R. J. DINIS-OLIVEIRA | 2015
Dans Forensic Science International (Vol.249, April 2015) Article : Périodique

"Krokodil" is the street name for the homemade injectable mixture that has been used as a cheap substitute for heroin. Its use begun in Russia and Ukraine and nowadays is being spread over several other countries. Desomorphine is the semi-synthe[...]

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The harmful chemistry behind "krokodil": Street-like synthesis and product analysis

E. A. ALVES ; J. X. SOARES ; C. M. AFONSO ; J. P. C. GRUND ; A. S. AGONIA ; S. M. CRAVO ; A. D. PEREIRA NETTO ; F. CARVALHO ; R. J. DINIS-OLIVEIRA | 2015
Dans Forensic Science International (Vol.257, December 2015) Article : Périodique

"Krokodil" is the street name for a drug, which has been attracting media and researchers attention due to its increasing spread and extreme toxicity. "Krokodil" is a homemade injectable mixture being used as a cheap substitute for heroin. Its u[...]

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