Article : Périodique

Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers

L. RIGAL ; C. ALEXANDRE-DUBROEUCQ ; R. DE BEAUREPAIRE ; C. LE JEUNNE ; P. JAURY |

Dans Alcohol and Alcoholism (Vol.47, n°4, July-August 2012)

AIMS: The aim of the study was to assess the proportions of 'high-risk' drinkers' abstinent or with 'low-risk' consumption levels 1 year after the initiation of high-dose baclofen. METHODS: This is a retrospective 'open' study; the outcome of [...]

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Article : Périodique

Titrated baclofen for high-risk alcohol consumption: a randomized placebo-controlled trial in out-patients with 1-year follow-up

L. RIGAL ; S. SIDORKIEWICZ ; J. M. TRELUYER ; E. PERRODEAU ; C. LE JEUNNE ; R. PORCHER ; P. JAURY |

Dans Addiction (Vol.115, n°7, July 2020)

Background and Aims: Baclofen is a promising drug for treating patients with alcohol-related disorders. Nevertheless, the first randomized clinical trials (mainly with target doses) reported inconsistent efficacy, possibly because of the effecti[...]

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