Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations

K. XU ; LICHTERMANN D. ; R. H. LIPSKY ; P. FRANKE ; X. LIU ; HU Y. ; L. CAO ; SCHWAB S. G. ; WILDENAUER D. B. ; C. H. BAU ; FERRO E. ; W. ASTOR ; T. FINCH ; J. TERRY ; TAUBMAN J. ; W. MAIER ; GOLDMAN D. | 2004
Périodique

ENGLISH : Context: Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D2 dopamine receptor gene (DRD2) with substance abuse are controversial. 0bjective: To determine whether sus[...]

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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

P. FRANKE ; B. WENDEL ; M. KNAPP ; SCHWAB S. G. ; NEEF D. ; W. MAIER ; WILDENAUER D. B. ; HOEHE M. R. | 2003
Dans European Psychiatry (Vol.18, n°1, February 2003) Article : Périodique

Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118 in exon 1 and IVS2+31 in intron 2) of the human µ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. -[...]

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