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Périodique
B. M. KINSEY ; T. R. KOSTEN ; F. M. ORSON | 2010Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At present, there are no effective pharmacological agents available to treat the addiction by bl[...]
Périodique
B. A. MARTELL ; F. M. ORSON ; J. POLING ; E. MITCHELL ; R. D. ROSSEN ; T. GARDNER ; T. R. KOSTEN | 2009CONTEXT. Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration–approved pharmacotherapy. OBJECTIVES. To evaluate the immunogenicity, safety, and efficacy of a novel cocaine vaccine to treat coc[...]
Périodique
F. M. ORSON ; B. M. KINSEY ; R. A. SINGH ; Y. WU ; T. GARDNER ; T. R. KOSTEN | 2008Conventional substance-abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advance[...]
Article : Périodique
The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abu[...]
