Anhedonia and substance-related symptoms in detoxified substance-dependent subjects: a correlation study

L. JANIRI ; G. MARTINOTTI ; DARIO T. ; REINA D. ; PAPARELLO F. ; G. POZZI ; G. ADDOLORATO ; M. DI GIANNANTONIO ; DE RISIO S. | 2005
Dans Neuropsychobiology (Vol.52, n°1, February 2005) Article : Périodique

Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, frequently occurring in mood disorders, as a negative symptom in schizophrenia, and in substance use disorders. In order to test a set of instr[...]

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Baclofen for the treatment of alcohol use disorder: the Cagliari Statement [Comment]

R. AGABIO ; J. M. A. SINCLAIR ; G. ADDOLORATO ; H. J. AUBIN ; E. M. BERAHA ; F. CAPUTO ; J. D. CHICK ; P. DE LA SELLE ; N. FRANCHITTO ; J. C. GARBUTT ; P. S. HABER ; M. HEYDTMAN ; P. JAURY ; A. R. LINGFORD-HUGHES ; K. C. MORLEY ; C. A. MULLER ; L. OWENS ; A. PASTOR ; L. M. PATERSON ; F. PELISSIER ; B. ROLLAND ; A. STAFFORD ; A. THOMPSON ; W. VAN DEN BRINK ; R. DE BEAUREPAIRE ; L. LEGGIO | 2018
Dans Lancet Psychiatry (The) (Vol.5, n°12, December 2018) Article : Périodique

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Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial

G. ADDOLORATO ; L. LEGGIO ; A. FERRULLI ; S. CARDONE ; G. BEDOGNI ; F. CAPUTO ; G. GASBARRINI ; R. LANDOLFI ; Baclofen Study Group | 2011
Dans Alcohol and Alcoholism (Vol.46, n°3, May-June 2011) Article : Périodique

AIMS: To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence. METHODS: We present a secondary analysis of a 12-week do[...]

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Neurobiochemical and clinical aspects of craving in alcohol addiction : a review

G. ADDOLORATO ; L. LEGGIO ; L. ABENAVOLI ; G. GASBARRINI | 2005
Périodique

ENGLISH : Craving plays an important role in the pathogenesis of alcohol dependence and relapse. In this review we have tried to analyse how many contrasting theories have been formulated in order to clarify the concept of craving. Many comple[...]

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The use of baclofen as a treatment for alcohol use disorder: A clinical practice perspective

R. DE BEAUREPAIRE ; J. M. A. SINCLAIR ; M. HEYDTMANN ; G. ADDOLORATO ; H. J. AUBIN ; E. M. BERAHA ; F. CAPUTO ; J. D. CHICK ; P. DE LA SELLE ; N. FRANCHITTO ; J. C. GARBUTT ; P. S. HABER ; P. JAURY ; A. R. LINGFORD-HUGHES ; K. C. MORLEY ; C. A. MULLER ; L. OWENS ; A. PASTOR ; L. M. PATERSON ; F. PELISSIER ; B. ROLLAND ; A. STAFFORD ; A. THOMPSON ; W. VAN DEN BRINK ; L. LEGGIO ; R. AGABIO | 2018
Dans Frontiers in Psychiatry (Vol.9, 2018) Article : Périodique

Alcohol use disorder (AUD) is a brain disorder associated with high rates of mortality and morbidity worldwide. Baclofen, a selective gamma-aminobutyric acid-B (GABA-B) receptor agonist, has emerged as a promising drug for AUD. The use of this d[...]

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