Titre : | Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption |
Titre traduit : | (Le sulfate d'éthyle : un métabolite direct de l'éthanol reflétant la consommation d'alcool.) |
Auteurs : | F. MARTIN WURST ; S. DRESEN ; J. P. ALLEN ; G. WIESBECK ; M. GRAF ; W. WEINNANN |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 204-211 / fig. ; tabl. |
Note générale : |
Addiction, 2006, 101, (2), 204-211
|
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés ALCOOL ; DEPISTAGE ; URINE ; METABOLITE ; PHARMACOCINETIQUE |
Résumé : | Background: Ethyl sulphate (EtS), a direct ethanol metabolite, appears to offer potential as a biomarker for recent alcohol consumption. Although its window of assessment is similar to that of ethyl glucuronide (EtG), there are differences between the two markers in their pathways for formation and degradation. Aims: (a) To assess the excretion of EtS compared to EtG and ethanol in drinking experiments with healthy volunteers, and (b) to elucidate the possibility of using the two metabolites for monitoring abstinence in substance use disorder patients during rehabilitation treatment. Design, setting, participants: (a) Nine drinking experiments were performed by six healthy volunteers (two females, four males), with a mean age of 34.1 years (2062), average oral intake of 0.2 g/kg ethanol (0.10.61), and having 74 spot urine samples. (b) Thirty-six substance abuse patients (mean age 41.9 years, 2059; 22 males, 14 females) in a rehabilitation programme after withdrawal, producing 98 urine samples. Ethyl glucuronide and ethyl sulphate were measured using liquid chromatography tandem mass spectrometry (LC-MS/MS) using d5-EtG and d5-EtS, respectively, as an internal standard. Findings: (a) Volunteers: EtG and EtS were detectable for up to 36 hours and reached the limits of determination in urine at 20.6 hours and 21.2 hours (median), respectively, after ethanol intake. EtG-100 (standardized to a creatinine of 100 mg/dl) reached its maximum level at 2.8 hours and EtS-100 at 2.1 hours (median) after the beginning of the experiment. Of the ethanol ingested, 0.022% was excreted as EtS in one volunteer. Eight samples were positive for EtS only and six for EtG only. Spearman's rank correlation coefficients of 0.84 (P |
Domaine : | Alcool / Alcohol |
Refs biblio. : | 37 |
Affiliation : |
Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Suisse. Switzerland. |
Numéro Toxibase : | 208794 |
Centre Emetteur : | 02 Coordonnateur |
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